Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.
A number of rat monoclonal antibodies of the IgG2b subclass have been used to deplete mice of T lymphocyte subsets. It has been possible to produce long-term depletion where antibodies are administered to mice thymectomized in their adult life, or short-term depletion in euthymic animals. It is ther...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1826299777103429632 |
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| author | Waldmann, H Cobbold, S Qin, S Benjamin, R Nash, T Welsh, J Tarnesby, G |
| author_facet | Waldmann, H Cobbold, S Qin, S Benjamin, R Nash, T Welsh, J Tarnesby, G |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | A number of rat monoclonal antibodies of the IgG2b subclass have been used to deplete mice of T lymphocyte subsets. It has been possible to produce long-term depletion where antibodies are administered to mice thymectomized in their adult life, or short-term depletion in euthymic animals. It is therefore feasible to ablate a T lymphocyte subpopulation at any stage in the course of an immune response and to examine in detail the role of a particular subset in the induction or effector phases of that response. We have used such ablative procedures to define the T cell subsets which participate in graft rejection, graft-versus-host disease, antigenic competition and antiviral and anti-self immunity and have attempted to exploit such knowledge to establish immunological tolerance in an adult animal. |
| first_indexed | 2024-03-07T05:07:06Z |
| format | Journal article |
| id | oxford-uuid:da4c6df5-6b15-44c0-bf95-7d83ecdbfab0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:07:06Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:da4c6df5-6b15-44c0-bf95-7d83ecdbfab02022-03-27T09:02:16ZMonoclonal antibodies for the depletion of specific subpopulations of lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:da4c6df5-6b15-44c0-bf95-7d83ecdbfab0EnglishSymplectic Elements at Oxford1987Waldmann, HCobbold, SQin, SBenjamin, RNash, TWelsh, JTarnesby, GA number of rat monoclonal antibodies of the IgG2b subclass have been used to deplete mice of T lymphocyte subsets. It has been possible to produce long-term depletion where antibodies are administered to mice thymectomized in their adult life, or short-term depletion in euthymic animals. It is therefore feasible to ablate a T lymphocyte subpopulation at any stage in the course of an immune response and to examine in detail the role of a particular subset in the induction or effector phases of that response. We have used such ablative procedures to define the T cell subsets which participate in graft rejection, graft-versus-host disease, antigenic competition and antiviral and anti-self immunity and have attempted to exploit such knowledge to establish immunological tolerance in an adult animal. |
| spellingShingle | Waldmann, H Cobbold, S Qin, S Benjamin, R Nash, T Welsh, J Tarnesby, G Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes. |
| title | Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes. |
| title_full | Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes. |
| title_fullStr | Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes. |
| title_full_unstemmed | Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes. |
| title_short | Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes. |
| title_sort | monoclonal antibodies for the depletion of specific subpopulations of lymphocytes |
| work_keys_str_mv | AT waldmannh monoclonalantibodiesforthedepletionofspecificsubpopulationsoflymphocytes AT cobbolds monoclonalantibodiesforthedepletionofspecificsubpopulationsoflymphocytes AT qins monoclonalantibodiesforthedepletionofspecificsubpopulationsoflymphocytes AT benjaminr monoclonalantibodiesforthedepletionofspecificsubpopulationsoflymphocytes AT nasht monoclonalantibodiesforthedepletionofspecificsubpopulationsoflymphocytes AT welshj monoclonalantibodiesforthedepletionofspecificsubpopulationsoflymphocytes AT tarnesbyg monoclonalantibodiesforthedepletionofspecificsubpopulationsoflymphocytes |