A mathematical model for germinal centre kinetics and affinity maturation.
We present a mathematical model which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immune response and on affinity maturation observed during the reaction. We show that antigen masking by antibodies which are produced by emerging plasma cells can drive affi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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