Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.

Acyl-enzyme complexes are intermediates in reactions catalyzed by many hydrolases and related enzymes which employ nucleophilic catalysis. However, most of the reported structural data on acyl-enzyme complexes has been acquired under noncatalytic conditions. Recent IR analyses have indicated that so...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Iqbal, A, Clifton, I, Bagonis, M, Kershaw, N, Domene, C, Claridge, T, Wharton, C, Schofield, C
פורמט:	Journal article
שפה:	English
יצא לאור:	2009

פריטים דומים

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates.
מאת: Iqbal, A, et al.
יצא לאור: (2011)

Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta-lactamase catalysis.
מאת: Aplin, RT, et al.
יצא לאור: (1990)

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.
מאת: Elkins, J, et al.
יצא לאור: (2005)

Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.
מאת: Wilmouth, R, et al.
יצא לאור: (1998)

Expression of arylamine N-acetyl transferase in the developing heart
מאת: Wakefield, L, et al.
יצא לאור: (2004)

SYNTHESIS OF L-ORNITHINES STEREOSPECIFICALLY DEUTERATED AT C-3
מאת: Baldwin, J, et al.
יצא לאור: (1993)

Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes
מאת: Lanyon-Hogg, T, et al.
יצא לאור: (2019)

Structural analyses on intermediates in serine protease catalysis.
מאת: Liu, B, et al.
יצא לאור: (2006)

Cyclobutanone mimics of intermediates in metallo-β-lactamase catalysis.
מאת: Abboud, M, et al.
יצא לאור: (2017)

Photometric estimation of proline and ornithine /
מאת: 202231 Chinard, Francis P.

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.
מאת: Kershaw, N, et al.
יצא לאור: (2002)

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.
מאת: Topf, M, et al.
יצא לאור: (2002)

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC
מאת: Ronan, JL, et al.
יצא לאור: (2018)

Crystal structures of the acyl transferases involved in the human cytosolic and mitochondrial fatty acid synthase
מאת: Misquitta, SA, et al.
יצא לאור: (2008)

Valproate toxicity and ornithine carbamoyltransferase deficiency.
מאת: Kay, J, et al.
יצא לאור: (1986)

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.
מאת: Wilmouth, R, et al.
יצא לאור: (2001)

Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors
מאת: Westwood, N, et al.
יצא לאור: (1997)

N-acetyl transferase 2 polymorphism and advanced stages of endometriosis in South Indian women.
מאת: Babu, K, et al.
יצא לאור: (2004)

Association between endometriosis and N-acetyl transferase 2 polymorphisms in a UK population.
מאת: Nakago, S, et al.
יצא לאור: (2001)

Identification of small molecules targeting homoserine acetyl transferase from Mycobacterium tuberculosis and Staphylococcus aureus
מאת: Chaudhary, Deepika, et al.
יצא לאור: (2023)

Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation
מאת: Hopkins, A, et al.
יצא לאור: (2017)

Enzyme-like Acyl Transfer Catalysis in a Bifunctional Organic Cage
מאת: Andrews, KG, et al.
יצא לאור: (2024)

Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.
מאת: Crabtree, MD, et al.
יצא לאור: (2004)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
מאת: Carpenter, E
יצא לאור: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
מאת: Chu, A
יצא לאור: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
מאת: Dong, Y
יצא לאור: (2018)

THE RELATIONSHIP OF ARGYROPHILIC PLAQUES AND NEUROFIBRILLARY TANGLES TO THE SEVERITY OF DEMENTIA AND CORTICAL CHOLINE ACETYL TRANSFERASE LEVELS IN ALZHEIMERS-DISEASE
מאת: Wilcock, G, et al.
יצא לאור: (1983)

Catalysis and tunnelling in the unimolecular decay of Criegee intermediates
מאת: Burd, T, et al.
יצא לאור: (2018)

Carbene-catalyzed alkylation of carboxylic esters via direct photoexcitation of acyl azolium intermediates
מאת: Ren, Shi-Cao, et al.
יצא לאור: (2021)

Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population.
מאת: Deguchi, M, et al.
יצא לאור: (2005)

Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases
מאת: McNeill, LA, et al.
יצא לאור: (2017)

Is JmjC oxygenase catalysis limited to demethylation?
מאת: Hopkinson, R, et al.
יצא לאור: (2013)

Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.
מאת: Wilmouth, R, et al.
יצא לאור: (1997)

Glutathione S-transferase variants and hypertension.
מאת: Delles, C, et al.
יצא לאור: (2008)

Computational analysis on missense mutation of ornithine transcarbamylase (OTCase) enzyme / Ernie Zuraida Ali
מאת: Ali, Ernie Zuraida
יצא לאור: (2020)

Organometallic mechanisms and catalysis : the role of reactive intermediates in organic processes/
מאת: 427264 Kochi, Jay K.
יצא לאור: (1978)

Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.
מאת: Rydzik, A, et al.
יצא לאור: (2014)

Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.
מאת: Hamed, R, et al.
יצא לאור: (2012)

Acyl transfer to lysine : an investigation acyl transfer across large rings
מאת: Chalfoun, David Joseph
יצא לאור: (2007)

Glutathione S-transferase gene deletions in myelodysplasia.
מאת: Atoyebi, W, et al.
יצא לאור: (1997)