Long survival in childhood lymphoblastic leukaemia.
Long term follow-up of 378 children with acute lymphoblastic leukaemia (ALL) treated at a single centre showed that at six years from diagnosis 202 (53%) were alive, of whom 140 (37%) remained in first remission. Only three children had a first relapse after six years. Children who survived six year...
| Главные авторы: | , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
1987
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| _version_ | 1826299827501137920 |
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| author | Chessells, J Hardisty, R Richards, S |
| author_facet | Chessells, J Hardisty, R Richards, S |
| author_sort | Chessells, J |
| collection | OXFORD |
| description | Long term follow-up of 378 children with acute lymphoblastic leukaemia (ALL) treated at a single centre showed that at six years from diagnosis 202 (53%) were alive, of whom 140 (37%) remained in first remission. Only three children had a first relapse after six years. Children who survived six years despite a single extramedullary relapse in the testis or CNS were likely to remain in second remission but patients with previous marrow or with multiple relapses continued at risk for up to ten years from diagnosis. Presenting factors influencing event-free survival were: leucocyte count, age and sex. After allowing for these factors morphological (FAB) subtype and liver enlargement retained their prognostic significance. Immunological type of ALL was not of independent prognostic significance, except for the small number of patients with B-ALL. Most factors lost their significance after 2-4 years. It is concluded that patients alive 6 years from diagnosis without relapse or even with a single extramedullary relapse of ALL, have a high chance of prolonged survival and cure. |
| first_indexed | 2024-03-07T05:07:52Z |
| format | Journal article |
| id | oxford-uuid:da8b98b2-8af7-44d7-bd1b-57fcebeb9e52 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:07:52Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:da8b98b2-8af7-44d7-bd1b-57fcebeb9e522022-03-27T09:03:59ZLong survival in childhood lymphoblastic leukaemia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:da8b98b2-8af7-44d7-bd1b-57fcebeb9e52EnglishSymplectic Elements at Oxford1987Chessells, JHardisty, RRichards, SLong term follow-up of 378 children with acute lymphoblastic leukaemia (ALL) treated at a single centre showed that at six years from diagnosis 202 (53%) were alive, of whom 140 (37%) remained in first remission. Only three children had a first relapse after six years. Children who survived six years despite a single extramedullary relapse in the testis or CNS were likely to remain in second remission but patients with previous marrow or with multiple relapses continued at risk for up to ten years from diagnosis. Presenting factors influencing event-free survival were: leucocyte count, age and sex. After allowing for these factors morphological (FAB) subtype and liver enlargement retained their prognostic significance. Immunological type of ALL was not of independent prognostic significance, except for the small number of patients with B-ALL. Most factors lost their significance after 2-4 years. It is concluded that patients alive 6 years from diagnosis without relapse or even with a single extramedullary relapse of ALL, have a high chance of prolonged survival and cure. |
| spellingShingle | Chessells, J Hardisty, R Richards, S Long survival in childhood lymphoblastic leukaemia. |
| title | Long survival in childhood lymphoblastic leukaemia. |
| title_full | Long survival in childhood lymphoblastic leukaemia. |
| title_fullStr | Long survival in childhood lymphoblastic leukaemia. |
| title_full_unstemmed | Long survival in childhood lymphoblastic leukaemia. |
| title_short | Long survival in childhood lymphoblastic leukaemia. |
| title_sort | long survival in childhood lymphoblastic leukaemia |
| work_keys_str_mv | AT chessellsj longsurvivalinchildhoodlymphoblasticleukaemia AT hardistyr longsurvivalinchildhoodlymphoblasticleukaemia AT richardss longsurvivalinchildhoodlymphoblasticleukaemia |