Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
<br/>Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp.<br/>Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and bio...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2019
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| _version_ | 1797098345712320512 |
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| author | Blacksell, SD Robinson, MT Newton, PN Ruanchaimun, S Salje, J Wangrangsimakul, T Wegner, MD Abdad, MY Bennett, AM Richards, AL Stenos, J Day, NPJ |
| author_facet | Blacksell, SD Robinson, MT Newton, PN Ruanchaimun, S Salje, J Wangrangsimakul, T Wegner, MD Abdad, MY Bennett, AM Richards, AL Stenos, J Day, NPJ |
| author_sort | Blacksell, SD |
| collection | OXFORD |
| description | <br/>Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp.<br/>Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and biosecurity, and presents the case for reclassification from Risk Group 3 to Risk Group 2 along with recommendations for safe working practices of risk-based activities during the manipulation of Orientia spp. in the laboratory.<br/>We recommend to reclassify Orientia spp. to Risk Group 2 based on the classification for RG2 pathogens as being moderate individual risk, low community risk. We recommend that low risk activities, can be performed within a biological safety cabinet located in a Biosafety Level (BSL) 2 core laboratory using standard personal protective equipment. But when the risk assessment indicates, such as high concentration and volume, or aerosol generation, then a higher biocontainment level is warranted. For, the majority of animal activities involving Orientia spp., Animal BSL 2 (ABSL2) is recommended however where high risk activities are performed including necropsies, Animal BSL (ABSL3) is recommended. |
| first_indexed | 2024-03-07T05:08:11Z |
| format | Journal article |
| id | oxford-uuid:daa6eba1-62fc-46d9-aab3-5310b53aeb81 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:08:11Z |
| publishDate | 2019 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:daa6eba1-62fc-46d9-aab3-5310b53aeb812022-03-27T09:04:51ZBiosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:daa6eba1-62fc-46d9-aab3-5310b53aeb81EnglishSymplectic Elements at OxfordSpringer Nature2019Blacksell, SDRobinson, MTNewton, PNRuanchaimun, SSalje, JWangrangsimakul, TWegner, MDAbdad, MYBennett, AMRichards, ALStenos, JDay, NPJ<br/>Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp.<br/>Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and biosecurity, and presents the case for reclassification from Risk Group 3 to Risk Group 2 along with recommendations for safe working practices of risk-based activities during the manipulation of Orientia spp. in the laboratory.<br/>We recommend to reclassify Orientia spp. to Risk Group 2 based on the classification for RG2 pathogens as being moderate individual risk, low community risk. We recommend that low risk activities, can be performed within a biological safety cabinet located in a Biosafety Level (BSL) 2 core laboratory using standard personal protective equipment. But when the risk assessment indicates, such as high concentration and volume, or aerosol generation, then a higher biocontainment level is warranted. For, the majority of animal activities involving Orientia spp., Animal BSL 2 (ABSL2) is recommended however where high risk activities are performed including necropsies, Animal BSL (ABSL3) is recommended. |
| spellingShingle | Blacksell, SD Robinson, MT Newton, PN Ruanchaimun, S Salje, J Wangrangsimakul, T Wegner, MD Abdad, MY Bennett, AM Richards, AL Stenos, J Day, NPJ Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2 |
| title | Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2 |
| title_full | Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2 |
| title_fullStr | Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2 |
| title_full_unstemmed | Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2 |
| title_short | Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2 |
| title_sort | biosafety and biosecurity requirements for orientia spp diagnosis and research recommendations for risk based biocontainment work practices and the case for reclassification to risk group 2 |
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