Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success of such vaccines in mice has not translated readily to effective malaria vaccines...

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Hlavní autoři: Schmidt, N, Podyminogin, R, Butler, N, Badovinac, V, Tucker, B, Bahjat, K, Lauer, P, Reyes-Sandoval, A, Hutchings, C, Moore, A, Gilbert, S, Hill, A, Bartholomay, L, Harty, J
Médium: Journal article
Jazyk:English
Vydáno: 2008