Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory

Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory

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The magnitude of negative selection on alleles involved in age-specific mortality decreases with age. This is the foundation of the evolutionary theory of senescence. Because of this decrease in negative selection with age, and because of the absence of reproduction after menopause, alleles involved...

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Bibliografiske detaljer
Main Authors:	Pavard, S, Metcalf, C
Format:	Journal article
Sprog:	English
Udgivet:	Public Library of Science 2007

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