Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory

Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory

Show other versions (1)

The magnitude of negative selection on alleles involved in age-specific mortality decreases with age. This is the foundation of the evolutionary theory of senescence. Because of this decrease in negative selection with age, and because of the absence of reproduction after menopause, alleles involved...

書目詳細資料
Main Authors:	Pavard, S, Metcalf, C
格式:	Journal article
語言:	English
出版:	Public Library of Science 2007

相似書籍

Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory
由: Pavard, S, et al.
出版: (2007)

Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases
由: Samuel Pavard, et al.
出版: (2020-12-01)

A Counselling Model for BRCA1/2 Genetic Susceptibility Testing
由: van Oostrom Iris, et al.
出版: (2004-02-01)

Why evolutionary biologists should be demographers.
由: Metcalf, C, et al.
出版: (2007)

All paths to fitness lead through demography
由: Metcalf, C, et al.
出版: (2007)

Insights Into the Impacts of BRCA Mutations on Clinicopathology and Management of Early-Onset Triple-Negative Breast Cancer
由: Fugui Ye, et al.
出版: (2021-01-01)

BRCA1 and BRCA2 Mutations Other Than the Founder Alleles Among Ashkenazi Jewish in the Population of Argentina
由: Angela R. Solano, et al.
出版: (2018-08-01)

Phylogenetic diversity theory sheds light on the structure of microbial communities.
由: James P O'Dwyer, et al.
出版: (2012-01-01)

Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.
由: Cox, D, et al.
出版: (2011)

Shedding Light on Shadows
由: Waltz, David L.
出版: (2008)

Shedding Light on Trust
由: Lesley Gill, et al.
出版: (2013-01-01)

Selected aspects of genetic counselling for <it>BRCA1 </it>mutation carriers
由: Gronwald Jacek
出版: (2007-03-01)

BRCA1, BRCA2 mutations and the association with the clinicopathological characteristics of women with early-onset breast cancer
由: Ghazali, Mohamad Bazli
出版: (2014)

Molecular profiling of BRCA1 and BRCA2 genes in Turkish patients with early-onset breast cancer
由: Taner Karakaya, et al.
出版: (2023-10-01)

Evolution and extinction of the giant rhinoceros Elasmotherium sibiricum sheds light on late Quaternary megafaunal extinctions
由: Kosintsev, P, et al.
出版: (2018)

New transitional fossil from late Jurassic of Chile sheds light on the origin of modern crocodiles
由: Fernando E. Novas, et al.
出版: (2021-07-01)

Genetic Variation of The BRCA1 and BRCA2 Genes in Macedonian Patients
由: Plaseska-Karanfilska Dijana, et al.
出版: (2012-12-01)

Selection on a Neural Gene Regulator Sheds Light on Human Evolution.
出版: (2005-12-01)

SHEDDING NEW LIGHT ON SUPERCONDUCTORS
由: Flavell, W, et al.
出版: (1994)

Shedding light on RSD in China
由: Song, L
出版: (2020)

Shedding light on Odysseus’ companions
由: Matrona Paleou
出版: (2023-06-01)

Shedding light on stellate cells
由: Andrew S Alexander, et al.
出版: (2018-09-01)

Shedding light on spawning in jellyfish
由: Laurinda A Jaffe
出版: (2018-01-01)

Breast Cancer Susceptibility Gene1 (BRCA1)
由: Wasiksiri, S., et al.
出版: (2002-07-01)

Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families
由: Ludmila Kaplun, et al.
出版: (2012-01-01)

Genetic Mutations and Mitochondrial Toxins Shed New Light on the Pathogenesis of Parkinson's Disease
由: Shigeto Sato, et al.
出版: (2011-01-01)

Immune diversity sheds light on missing variation in worldwide genetic diversity panels.
由: Laurent Abi-Rached, et al.
出版: (2018-01-01)

The In Vitro Antimicrobial Susceptibility of <i>Borrelia burgdorferi</i> sensu lato: Shedding Light on the Known Unknowns
由: Klaus-Peter Hunfeld, et al.
出版: (2023-09-01)

Stratigraphic reassessment of Grotta Romanelli sheds light on Middle-Late Pleistocene palaeoenvironments and human settling in the Mediterranean
由: Pierluigi Pieruccini, et al.
出版: (2022-08-01)

Senescence of reproduction may explain adaptive menopause in humans: a test of the "mother" hypothesis.
由: Pavard, S, et al.
出版: (2008)

Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease
由: Tomoyuki Asano, et al.
出版: (2017-09-01)

A role of <it>BRCA1 </it>and <it>BRCA2 </it>germline mutations in breast cancer susceptibility within Sardinian population
由: Lovicu Mario, et al.
出版: (2009-07-01)

BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia
由: Tamboom Kristiina, et al.
出版: (2010-04-01)

BRCA2 mutations and triple-negative breast cancer.
由: Peter Meyer, et al.
出版: (2012-01-01)

Dynamic genetic architecture of yeast response to environmental perturbation shed light on origin of cryptic genetic variation.
由: Yanjun Zan, et al.
出版: (2020-05-01)

ISOLED 2015 SHEDS LIGHT TO FUTURE LIGHTING SOLUTIONS
由: MPRC, Pusat Media & Perhubungan Awam
出版: (2015)

Shedding light on pilot-wave phenomena
由: Brun, Pierre-Thomas, et al.
出版: (2018)

'Jade' sheds light on babies with jaundice.
由: Evans, Albert, author
出版: (1997)

Shedding Light on the Italian Mesophotic Spongofauna
由: Margherita Toma, et al.
出版: (2024-11-01)

Shedding light on neurocysticercosis misinformation in the media
由: Alarcón-Elbal P. M., et al.
出版: (2024-12-01)