An N-ethyl-n-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

An N-ethyl-n-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

Show other versions (1)

Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, maybe due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is stimulated by CRH, and we report a mouse model for C...

Full description

Bibliographic Details
Main Authors:	Bentley, L, Esapa, C, Nesbit, M, Head, R, Evans, H, Lath, D, Scudamore, C, Hough, T, Podrini, C, Hannan, F, Fraser, W, Croucher, P, Brown, M, Brown, S, Cox, R, Thakker, R
Format:	Journal article
Language:	English
Published:	2014

Similar Items

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.
by: Bentley, L, et al.
Published: (2014)

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models
by: Esapa, C, et al.
Published: (2015)

Mice with an N-ethyl-N-nitrosourea (ENU) induced Tyr209Asn mutation in natriuretic peptide receptor 3 (NPR3) provide a model for kyphosis associated with activation of the MAPK signaling pathway
by: Esapa, C, et al.
Published: (2016)

An N-ethyl-N-nitrosourea (ENU) mutagenized mouse model for autosomal dominant non-syndromic kyphoscoliosis due to vertebral fusion
by: Esapa, C, et al.
Published: (2018)

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis
by: Esapa, C, et al.
Published: (2012)

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.
by: Christopher T Esapa, et al.
Published: (2015-01-01)

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.
by: Christopher T Esapa, et al.
Published: (2012-01-01)

Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway.
by: Christopher T Esapa, et al.
Published: (2016-01-01)

N-ethyl-N-nitrosourea-induced adaptor protein 2 sigma subunit 1 ( Ap2s1 ) mutations establish Ap2s1 loss-of-function mice
by: Gorvin, C, et al.
Published: (2017)

Mutational Analysis of N-Ethyl-N-Nitrosourea (ENU) in the Fission Yeast Schizosaccharomyces pombe
by: Rafael Hoyos-Manchado, et al.
Published: (2020-03-01)

Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.
by: Ming-Jen Lee, et al.
Published: (2009-11-01)

Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.
by: Keays, D, et al.
Published: (2006)

Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice
by: Lucienne Chatenoud, et al.
Published: (2022-06-01)

Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.
by: Vivian Capilla-Gonzalez, et al.
Published: (2012-01-01)

Spontaneous inflammatory pain model from a mouse line with <it>N</it>-ethyl-<it>N</it>-nitrosourea mutagenesis
by: Chen Tsung-Chieh, et al.
Published: (2012-05-01)

<i>Socrates:</i> A Novel N-Ethyl-N-nitrosourea-Induced Mouse Mutant with Audiogenic Epilepsy
by: Elena G. Varlamova, et al.
Published: (2023-12-01)

N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels
by: Hrabé de Angelis Martin, et al.
Published: (2009-06-01)

Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans
by: Omar A. Itani, et al.
Published: (2016-02-01)

A Mouse with a Ser1386Pro Mutation in the C-propeptide Domain of col2aI Provides a Model for Spondyloepiphyseal Dysplasia Congenita
by: Esapa, C, et al.
Published: (2008)

Genetic models of bone disease using ENU mutagenesis
by: Brown, S, et al.
Published: (2009)

Vanillic acid protects mortality and toxicity induced by N-ethyl-N-nitrosourea in mice; in vivo model of chronic lymphocytic leukemia
by: Ahmad Salimi, et al.
Published: (2024-06-01)

An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.
by: Silayuv E Bongfen, et al.
Published: (2012-01-01)

N-ethyl-n-nitrosourea induced leukaemia in a mouse model through upregulation of vascular endothelial growth factor and evading apoptosis
by: Abdullahi, Aliyu, et al.
Published: (2020)

N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3′ Splice Site Function in Vivo
by: Omar A. Itani, et al.
Published: (2016-06-01)

Effects of N-methyl-N-nitrosourea on seed germination of Stevia rebaudiana
by: Ahmad, Lyena Watty Zuraine, et al.
Published: (2019)

Effects of N-Methyl-N-Nitrosourea on seed germination of Stevia rebaudiana
by: Lyena Watty Zuraine Ahmad,, et al.
Published: (2019)

Expression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors.
by: Dahia, P, et al.
Published: (1997)

Alcohol dysregulates corticotropin-releasing-hormone (CRH) promoter activity by interfering with the negative glucocorticoid response element (nGRE).
by: Magdalena M Przybycien-Szymanska, et al.
Published: (2011-01-01)

Preventive effect of Oenothera rosea on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats
by: Almora-Pinedo Y, et al.
Published: (2017-12-01)

Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea
by: Keiko Inami, et al.
Published: (2019-12-01)

A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation.
by: Piret, S, et al.
Published: (2012)

<i>N</i>-Ethyl-<i>n</i>-Nitrosourea Induced Leukaemia in a Mouse Model through Upregulation of Vascular Endothelial Growth Factor and Evading Apoptosis
by: Abdullahi Aliyu, et al.
Published: (2020-03-01)

Continuous administration of human corticotropin-releasing hormone in the absence of glucocorticoid feedback in man.
by: Ur, E, et al.
Published: (1995)

HSP70 cleavage-induced photoreceptor cell death caused by N-methyl-N-nitrosourea
by: Yoshiki Koriyama, et al.
Published: (2016-01-01)

Genotoxic and chemopreventive potentials of ethanol leaves extract of Annona muricata on N-Ethyl-N-Nitrosourea-induced pro-leukaemia carcinogen in mice model by bone marrow micronucleus assay
by: Oluwaseyi Bamisaye, et al.
Published: (2022-12-01)

Characteristics of rod regeneration in a novel zebrafish retinal degeneration model using N-methyl-N-nitrosourea (MNU)
by: Tappeiner, C, et al.
Published: (2013)

Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
by: Al-Salih, Hutheyfa A. H., et al.
Published: (2011)

Alteration of serum biochemical parameters and urinalysis in Sprague Dawley rats administered with N-methyl-N-nitrosourea
by: Hakimi, M. K., et al.
Published: (2012)

Lycium barbarum glycopeptide (wolfberry extract) slows N-methyl-N-nitrosourea-induced degradation of photoreceptors
by: Qihang Kong, et al.
Published: (2024-01-01)

The Influence of Physical Training on the Immune System of Rats during N-methyl-N-nitrosourea-Induced Carcinogenesis
by: Iwona Malicka, et al.
Published: (2022-10-01)