Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

OBJECTIVE: Identify gene changes in articular cartilage of the medial tibial plateau (MTP) at 2, 4 and 8 weeks after destabilisation of the medial meniscus (DMM) in mice. Compare our data with previously published datasets to ascertain dysregulated pathways and genes in osteoarthritis. Design: RNA w...

Full description

Bibliographic Details
Main Authors:	Gardiner, MD, Vincent, T, Driscoll, C, Burleigh, A, Bou-Gharios, G, Saklatvala, J, Nagase, H, Chanalaris, A
Format:	Journal article
Language:	English
Published:	2014

Similar Items

Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.
by: Burleigh, A, et al.
Published: (2012)

JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis.
by: Ismail, H, et al.
Published: (2015)

Regulation of nerve growth factor in the articular cartilage causes pain in murine OA
by: Driscoll, C, et al.
Published: (2014)

Generation of Tamoxifen inducible mice to express hTIMP-3 in articular chondrocytes to block degradation of cartilage in osteoarthritis
by: Lo Cascio, L, et al.
Published: (2012)

Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo.
by: Chong, K, et al.
Published: (2013)

Gene expression profiling and proteomic analysis of cartilage degradation in a mouse model of osteoarthritis
by: Gardiner, MD, et al.
Published: (2012)

Pathogenic protease expression in murine OA is critically dependent upon mechanical joint loading
by: Burleigh, A, et al.
Published: (2012)

CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy
by: Miotla Zarebska, J, et al.
Published: (2016)

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.
by: Chia, S, et al.
Published: (2009)

IL18 IS SECRETED UPON JOINT INJURY AND IS A KEY PATHOGENIC CYTOKINE IN MURINE OSTEOARTHRITIS
by: Vincent, T, et al.
Published: (2014)

Retinoic acid is regulated by cartilage injury and is anti-inflammatory in hand osteoarthritis
by: Zhu, L, et al.
Published: (2018)

The c-jun N-terminal kinase (JNK)-2 controls articular cartilage aggrecan degradation and progression of experimental osteoarthritis
by: Ismail, H, et al.
Published: (2014)

Pericellular matrix of articular cartilage. A novel mechanotransduction mechanism in articular chondrocytes?
by: Vincent, T, et al.
Published: (2006)

Basic fibroblast growth factor: An extracellular mechanotransducer in articular cartilage?
by: Vincent, T, et al.
Published: (2006)

Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?
by: Vincent, T, et al.
Published: (2006)

Is the response of cartilage to injury relevant to osteoarthritis?
by: Vincent, T, et al.
Published: (2008)

Articular Cartilage Regeneration in Osteoarthritis
by: Livia Roseti, et al.
Published: (2019-10-01)

Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis
by: Hiroyuki Nakamura, et al.
Published: (2020-06-01)

Pathology of the calcified zone of articular cartilage in post-traumatic osteoarthritis in rat knees.
by: Melissa Schultz, et al.
Published: (2015-01-01)

Fibromodulin and tenascin N are potential biomarkers of post-traumatic OA
by: Papadopoulou, A, et al.
Published: (2014)

Generation of a mouse line harboring a Bi-transgene expressing luciferase and tamoxifen-activatable creER(T2) recombinase in cartilage.
by: Lo Cascio, L, et al.
Published: (2014)

The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics
by: Lorenzo Ramos-Mucci, et al.
Published: (2022-05-01)

Differential inflammatory gene expression patterns in JNK2 knockout mice in response to IL1, cartilage injury and surgically induced osteoarthritis
by: Ismail, HM, et al.
Published: (2016)

Structural and regulatory components of the pericellular matrix of young and mature articular cartilage
by: McLean, C, et al.
Published: (2010)

TGF-b signaling in cartilage homeostasis and osteoarthritis.
by: Finnson, K, et al.
Published: (2012)

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.
by: Lim, N, et al.
Published: (2014)

Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage
by: Sawaji, Y, et al.
Published: (2009)

CARTILAGE INJURY REGULATES NERVE GROWTH FACTOR (NGF) IN VTTRO AND IN VIVO AND DRIVES PAINFUL BEHAVIOUR IN MURINE OA
by: Driscoll, C, et al.
Published: (2014)

Proteomic analysis of cartilage protein profiles in a mouse model of osteoarthritis
by: Gardiner, MD, et al.
Published: (2011)

The dependence of FGF2 on murine cartilage injury responses
by: Chong, K, et al.
Published: (2011)

Induction of interleukin-1 in articular cartilage by explantation and cutting.
by: Gruber, J, et al.
Published: (2004)

The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis
by: Md. Zahirul Haque Bhuyan, et al.
Published: (2017-06-01)

Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
by: Vincent, T, et al.
Published: (2002)

Nociceptive sensitizers are regulated in damaged joint tissues, including the articular cartilage, when osteoarthritic mice display pain behaviour
by: Driscoll, C, et al.
Published: (2015)

Connective tissue growth factor: matrix localisation, regulation and possible function in articular cartilage
by: McLean, C, et al.
Published: (2010)

Nanomechanical phenotype of chondroadherin-null murine articular cartilage
by: Batista, Michael A., et al.
Published: (2014)

A SINGLE ADMINISTRATION OF DEXAMETHASONE MAY PROTECT TIBIAL PLATEAU CARTILAGE IN A MECHANICALLY STABLE SURGICAL MODEL OF POST TRAUMATIC OSTEOARTHRITIS
by: Jin, H, et al.
Published: (2014)

T2* measurement of the knee articular cartilage in osteoarthritis at 3T.
by: Newbould, R, et al.
Published: (2012)

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis
by: Kentaro Homan, et al.
Published: (2024-03-01)

Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy
by: Chenyu Rao, et al.
Published: (2022-08-01)