The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions
Vascular homoeostasis, development and disease critically depend on the regulation of endothelial cell-cell junctions. Here we uncover a new role for the F-BAR protein pacsin2 in the control of VE-cadherin-based endothelial adhesion. Pacsin2 concentrates at focal adherens junctions (FAJs) that are e...
Main Authors: | Dorland, Y, Malinova, T, Van Stalborch, A, Grieve, A, Van Geemen, D, Jansen, N, De Kreuk, B, Nawaz, K, Kole, J, Geerts, D, Musters, R, De Rooij, J, Hordijk, P, Huveneers, S |
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Format: | Journal article |
Language: | English |
Published: |
Nature Publishing Group
2016
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