A multi-country analysis of COVID-19 hospitalizations by vaccination status
<strong>Background<br></strong> Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patie...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2023
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| _version_ | 1826311465645113344 |
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| author | Gonçalves, BP Jassat, W Baruch, J Hashmi, M Rojek, A Dasgupta, A Martin-Loeches, I Reyes, LF Piubelli, C Citarella, BW Kartsonaki, C Lefèvre, B López Revilla, JW Lunn, M Harrison, EM Kraemer, MUG Shrapnel, S Horby, P Bisoffi, Z Olliaro, PL Merson, L |
| author2 | ISARIC Clinical Characterisation Group |
| author_facet | ISARIC Clinical Characterisation Group Gonçalves, BP Jassat, W Baruch, J Hashmi, M Rojek, A Dasgupta, A Martin-Loeches, I Reyes, LF Piubelli, C Citarella, BW Kartsonaki, C Lefèvre, B López Revilla, JW Lunn, M Harrison, EM Kraemer, MUG Shrapnel, S Horby, P Bisoffi, Z Olliaro, PL Merson, L |
| author_sort | Gonçalves, BP |
| collection | OXFORD |
| description | <strong>Background<br></strong>
Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes.
<br><strong>Methods<br></strong>
Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed.
<br><strong>Findings<br></strong>
While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed.
<br><strong>Conclusions<br></strong>
These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history.
<br><strong>Funding<br></strong>
This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section. |
| first_indexed | 2024-03-07T08:10:15Z |
| format | Journal article |
| id | oxford-uuid:db5c1900-2588-40ec-8f0c-94d34e4186bf |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:10:15Z |
| publishDate | 2023 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:db5c1900-2588-40ec-8f0c-94d34e4186bf2023-11-15T11:05:10ZA multi-country analysis of COVID-19 hospitalizations by vaccination statusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:db5c1900-2588-40ec-8f0c-94d34e4186bfEnglishSymplectic ElementsCell Press2023Gonçalves, BPJassat, WBaruch, JHashmi, MRojek, ADasgupta, AMartin-Loeches, IReyes, LFPiubelli, CCitarella, BWKartsonaki, CLefèvre, BLópez Revilla, JWLunn, MHarrison, EMKraemer, MUGShrapnel, SHorby, PBisoffi, ZOlliaro, PLMerson, LISARIC Clinical Characterisation Group<strong>Background<br></strong> Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. <br><strong>Methods<br></strong> Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. <br><strong>Findings<br></strong> While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. <br><strong>Conclusions<br></strong> These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. <br><strong>Funding<br></strong> This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section. |
| spellingShingle | Gonçalves, BP Jassat, W Baruch, J Hashmi, M Rojek, A Dasgupta, A Martin-Loeches, I Reyes, LF Piubelli, C Citarella, BW Kartsonaki, C Lefèvre, B López Revilla, JW Lunn, M Harrison, EM Kraemer, MUG Shrapnel, S Horby, P Bisoffi, Z Olliaro, PL Merson, L A multi-country analysis of COVID-19 hospitalizations by vaccination status |
| title | A multi-country analysis of COVID-19 hospitalizations by vaccination status |
| title_full | A multi-country analysis of COVID-19 hospitalizations by vaccination status |
| title_fullStr | A multi-country analysis of COVID-19 hospitalizations by vaccination status |
| title_full_unstemmed | A multi-country analysis of COVID-19 hospitalizations by vaccination status |
| title_short | A multi-country analysis of COVID-19 hospitalizations by vaccination status |
| title_sort | multi country analysis of covid 19 hospitalizations by vaccination status |
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