Convergent pathways in Parkinson’s disease
Preferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson's disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and architecture, which make them particularly suscept...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Springer Berlin Heidelberg
2017
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| _version_ | 1826299997718577152 |
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| author | Cherubini, M Wade-Martins, R |
| author_facet | Cherubini, M Wade-Martins, R |
| author_sort | Cherubini, M |
| collection | OXFORD |
| description | Preferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson's disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and architecture, which make them particularly susceptible to stress factors. Here, we report a concise overview of some of the cell mechanisms that may exacerbate DAn sensitivity and loss in PD. In particular, we highlight how defective protein sorting and clearance, endoplasmic reticulum stress, calcium dyshomeostasis and intracellular trafficking converge to contribute synergistically to neuronal dysfunction in PD pathogenesis. |
| first_indexed | 2024-03-07T05:10:26Z |
| format | Journal article |
| id | oxford-uuid:db6025ad-7d2d-4ae5-bd80-6562441e2cb1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:10:26Z |
| publishDate | 2017 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | oxford-uuid:db6025ad-7d2d-4ae5-bd80-6562441e2cb12022-03-27T09:10:03ZConvergent pathways in Parkinson’s diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:db6025ad-7d2d-4ae5-bd80-6562441e2cb1EnglishSymplectic Elements at OxfordSpringer Berlin Heidelberg2017Cherubini, MWade-Martins, RPreferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson's disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and architecture, which make them particularly susceptible to stress factors. Here, we report a concise overview of some of the cell mechanisms that may exacerbate DAn sensitivity and loss in PD. In particular, we highlight how defective protein sorting and clearance, endoplasmic reticulum stress, calcium dyshomeostasis and intracellular trafficking converge to contribute synergistically to neuronal dysfunction in PD pathogenesis. |
| spellingShingle | Cherubini, M Wade-Martins, R Convergent pathways in Parkinson’s disease |
| title | Convergent pathways in Parkinson’s disease |
| title_full | Convergent pathways in Parkinson’s disease |
| title_fullStr | Convergent pathways in Parkinson’s disease |
| title_full_unstemmed | Convergent pathways in Parkinson’s disease |
| title_short | Convergent pathways in Parkinson’s disease |
| title_sort | convergent pathways in parkinson s disease |
| work_keys_str_mv | AT cherubinim convergentpathwaysinparkinsonsdisease AT wademartinsr convergentpathwaysinparkinsonsdisease |