Evaluating evolutionary models of stress-induced mutagenesis in bacteria.
Increased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct s...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1797098501799149568 |
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| author | Maclean, C Torres-Barceló, C Moxon, R |
| author_facet | Maclean, C Torres-Barceló, C Moxon, R |
| author_sort | Maclean, C |
| collection | OXFORD |
| description | Increased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct selection for increased stress tolerance, second-order selection for increased evolvability and genetic drift. Further progress in our understanding of the evolutionary biology of stress and mutagenesis will require a more detailed understanding both of the patterns of stress encountered by bacteria in nature and of the mutations that are produced under stress. |
| first_indexed | 2024-03-07T05:10:28Z |
| format | Journal article |
| id | oxford-uuid:db61f83a-12bf-4aa6-891e-7374b468d604 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:10:28Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:db61f83a-12bf-4aa6-891e-7374b468d6042022-03-27T09:10:09ZEvaluating evolutionary models of stress-induced mutagenesis in bacteria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:db61f83a-12bf-4aa6-891e-7374b468d604EnglishSymplectic Elements at Oxford2013Maclean, CTorres-Barceló, CMoxon, RIncreased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct selection for increased stress tolerance, second-order selection for increased evolvability and genetic drift. Further progress in our understanding of the evolutionary biology of stress and mutagenesis will require a more detailed understanding both of the patterns of stress encountered by bacteria in nature and of the mutations that are produced under stress. |
| spellingShingle | Maclean, C Torres-Barceló, C Moxon, R Evaluating evolutionary models of stress-induced mutagenesis in bacteria. |
| title | Evaluating evolutionary models of stress-induced mutagenesis in bacteria. |
| title_full | Evaluating evolutionary models of stress-induced mutagenesis in bacteria. |
| title_fullStr | Evaluating evolutionary models of stress-induced mutagenesis in bacteria. |
| title_full_unstemmed | Evaluating evolutionary models of stress-induced mutagenesis in bacteria. |
| title_short | Evaluating evolutionary models of stress-induced mutagenesis in bacteria. |
| title_sort | evaluating evolutionary models of stress induced mutagenesis in bacteria |
| work_keys_str_mv | AT macleanc evaluatingevolutionarymodelsofstressinducedmutagenesisinbacteria AT torresbarceloc evaluatingevolutionarymodelsofstressinducedmutagenesisinbacteria AT moxonr evaluatingevolutionarymodelsofstressinducedmutagenesisinbacteria |