Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation.
Deep Brain Stimulation (DBS) is an effective treatment for several neurological and psychiatric disorders. In order to gain insights into the therapeutic mechanisms of DBS and to advance future therapies a better understanding of the effects of DBS on large-scale brain networks is required.In this p...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
Elsevier
2016
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| _version_ | 1826300003410247680 |
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| author | Oswal, A Jha, A Neal, S Reid, A Bradbury, D Aston, P Limousin, P Foltynie, T Zrinzo, L Brown, P Litvak, V |
| author_facet | Oswal, A Jha, A Neal, S Reid, A Bradbury, D Aston, P Limousin, P Foltynie, T Zrinzo, L Brown, P Litvak, V |
| author_sort | Oswal, A |
| collection | OXFORD |
| description | Deep Brain Stimulation (DBS) is an effective treatment for several neurological and psychiatric disorders. In order to gain insights into the therapeutic mechanisms of DBS and to advance future therapies a better understanding of the effects of DBS on large-scale brain networks is required.In this paper, we describe an experimental protocol and analysis pipeline for simultaneously performing DBS and intracranial local field potential (LFP) recordings at a target brain region during concurrent magnetoencephalography (MEG) measurement. Firstly we describe a phantom setup that allowed us to precisely characterise the MEG artefacts that occurred during DBS at clinical settings.Using the phantom recordings we demonstrate that with MEG beamforming it is possible to recover oscillatory activity synchronised to a reference channel, despite the presence of high amplitude artefacts evoked by DBS. Finally, we highlight the applicability of these methods by illustrating in a single patient with Parkinson's disease (PD), that changes in cortical-subthalamic nucleus coupling can be induced by DBS.To our knowledge this paper provides the first technical descriptions of a recording and analysis pipeline for combining simultaneous cortical recordings using MEG, with intracranial LFP recordings of a target brain nucleus during DBS. |
| first_indexed | 2024-03-07T05:10:31Z |
| format | Journal article |
| id | oxford-uuid:db657858-2c59-464e-a41a-269e3ec49585 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:10:31Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:db657858-2c59-464e-a41a-269e3ec495852022-03-27T09:10:17ZAnalysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:db657858-2c59-464e-a41a-269e3ec49585EnglishSymplectic Elements at OxfordElsevier2016Oswal, AJha, ANeal, SReid, ABradbury, DAston, PLimousin, PFoltynie, TZrinzo, LBrown, PLitvak, VDeep Brain Stimulation (DBS) is an effective treatment for several neurological and psychiatric disorders. In order to gain insights into the therapeutic mechanisms of DBS and to advance future therapies a better understanding of the effects of DBS on large-scale brain networks is required.In this paper, we describe an experimental protocol and analysis pipeline for simultaneously performing DBS and intracranial local field potential (LFP) recordings at a target brain region during concurrent magnetoencephalography (MEG) measurement. Firstly we describe a phantom setup that allowed us to precisely characterise the MEG artefacts that occurred during DBS at clinical settings.Using the phantom recordings we demonstrate that with MEG beamforming it is possible to recover oscillatory activity synchronised to a reference channel, despite the presence of high amplitude artefacts evoked by DBS. Finally, we highlight the applicability of these methods by illustrating in a single patient with Parkinson's disease (PD), that changes in cortical-subthalamic nucleus coupling can be induced by DBS.To our knowledge this paper provides the first technical descriptions of a recording and analysis pipeline for combining simultaneous cortical recordings using MEG, with intracranial LFP recordings of a target brain nucleus during DBS. |
| spellingShingle | Oswal, A Jha, A Neal, S Reid, A Bradbury, D Aston, P Limousin, P Foltynie, T Zrinzo, L Brown, P Litvak, V Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation. |
| title | Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation. |
| title_full | Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation. |
| title_fullStr | Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation. |
| title_full_unstemmed | Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation. |
| title_short | Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation. |
| title_sort | analysis of simultaneous meg and intracranial lfp recordings during deep brain stimulation a protocol and experimental validation |
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