HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
We have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. Th...
| Main Authors: | , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2002
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| _version_ | 1826300031440781312 |
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| author | Addo, M Altfeld, M Rathod, A Yu, M Yu, X Goulder, P Rosenberg, E Walker, B |
| author_facet | Addo, M Altfeld, M Rathod, A Yu, M Yu, X Goulder, P Rosenberg, E Walker, B |
| author_sort | Addo, M |
| collection | OXFORD |
| description | We have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. The epitope was shown to be highly conserved among HIV clade B sequences and is restricted by HLA-A*3303, an HLA allele commonly seen in Asian and west-African populations. |
| first_indexed | 2024-03-07T05:10:57Z |
| format | Journal article |
| id | oxford-uuid:db873872-7c47-4c2c-895f-41642dc7fdb1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:10:57Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:db873872-7c47-4c2c-895f-41642dc7fdb12022-03-27T09:11:16ZHIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:db873872-7c47-4c2c-895f-41642dc7fdb1EnglishSymplectic Elements at Oxford2002Addo, MAltfeld, MRathod, AYu, MYu, XGoulder, PRosenberg, EWalker, BWe have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. The epitope was shown to be highly conserved among HIV clade B sequences and is restricted by HLA-A*3303, an HLA allele commonly seen in Asian and west-African populations. |
| spellingShingle | Addo, M Altfeld, M Rathod, A Yu, M Yu, X Goulder, P Rosenberg, E Walker, B HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. |
| title | HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. |
| title_full | HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. |
| title_fullStr | HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. |
| title_full_unstemmed | HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. |
| title_short | HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. |
| title_sort | hiv 1 vpu represents a minor target for cytotoxic t lymphocytes in hiv 1 infection |
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