Microarray analysis of mdx mice expressing high levels of utrophin: therapeutic implications for dystrophin deficiency.

Microarray analysis of mdx mice expressing high levels of utrophin: therapeutic implications for dystrophin deficiency.

Duchenne Muscular Dystrophy (DMD) is a fatal muscle wasting disorder caused by dystrophin deficiency. Previous work suggested that increased expression of the dystrophin-related protein utrophin in the mdx mouse can reduce the dystrophic pathophysiology. Physiological tests showed that the transgeni...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Baban, D, Davies, K
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2008

Eitemau Tebyg

Functional substitution by TAT-utrophin in dystrophin-deficient mice.
gan: Kevin J Sonnemann, et al.
Cyhoeddwyd: (2009-05-01)

Muscle structure influences utrophin expression in mdx mice.
gan: Glen B Banks, et al.
Cyhoeddwyd: (2014-06-01)

Increased neointimal thickening in dystrophin-deficient mdx mice.
gan: Uwe Rauch, et al.
Cyhoeddwyd: (2012-01-01)

Peptide Nucleic Acid Promotes Systemic Dystrophin Expression and Functional Rescue in Dystrophin-deficient mdx Mice
gan: Xianjun Gao, et al.
Cyhoeddwyd: (2015-01-01)

Peptide Nucleic Acid Promotes Systemic Dystrophin Expression and Functional Rescue in Dystrophin-Deficient mdx Mice
gan: Xianjun Gao, et al.
Cyhoeddwyd: (2020-12-01)

Marginal level dystrophin expression improves clinical outcome in a strain of dystrophin/utrophin double knockout mice.
gan: Dejia Li, et al.
Cyhoeddwyd: (2010-12-01)

Muscle regeneration in dystrophin-deficient <it>mdx </it>mice studied by gene expression profiling
gan: van Ommen G-JB, et al.
Cyhoeddwyd: (2005-07-01)

Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.
gan: Wakefield, P, et al.
Cyhoeddwyd: (2000)

Rescu of severely affected dystrophin/utrophin deficient mice by morpholino-oligomer mediated exon skipping
gan: Goyenvalle, A, et al.
Cyhoeddwyd: (2010)

Non-toxic ubiquitous over-expression of utrophin in the mdx mouse.
gan: Fisher, R, et al.
Cyhoeddwyd: (2001)

Prevention of pathology in mdx mice by expression of utrophin: analysis using an inducible transgenic expression system.
gan: Squire, S, et al.
Cyhoeddwyd: (2002)

Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin-deficient mice and Duchenne muscular dystrophy
gan: Perkins, K, et al.
Cyhoeddwyd: (2018)

Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient mice.
gan: Rafael, J, et al.
Cyhoeddwyd: (2000)

Non-toxic ubiquitous overexpression of utrophin in the mdx mouse.
gan: Fisher, R, et al.
Cyhoeddwyd: (2000)

Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping.
gan: Goyenvalle, A, et al.
Cyhoeddwyd: (2010)

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO
gan: Yin, H, et al.
Cyhoeddwyd: (2010)

Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
gan: Gang Han, et al.
Cyhoeddwyd: (2016-03-01)

The utrophin and dystrophin genes share similarities in genomic structure.
gan: Pearce, M, et al.
Cyhoeddwyd: (1993)

Metabolic profiles of dystrophin and utrophin expression in mouse models of Duchenne muscular dystrophy.
gan: Griffin, J, et al.
Cyhoeddwyd: (2002)

A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice.
gan: Yin, H, et al.
Cyhoeddwyd: (2009)

Immunogold confirmation that utrophin is localized to the normal position of dystrophin in dystrophin-negative transgenic mouse muscle.
gan: Culle, M, et al.
Cyhoeddwyd: (2001)

Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression
gan: Angelina M. Georgieva, et al.
Cyhoeddwyd: (2022-07-01)

Effect of 2-Aminoethoxydiphenyl Borate on the State of Skeletal Muscles in Dystrophin-Deficient mdx Mice
gan: Mikhail V. Dubinin, et al.
Cyhoeddwyd: (2024-12-01)

The proton pump inhibitor lansoprazole improves the skeletal phenotype in dystrophin deficient mdx mice.
gan: Arpana Sali, et al.
Cyhoeddwyd: (2013-01-01)

A-utrophin up-regulation in mdx skeletal muscle is independent of regeneration.
gan: Weir, A, et al.
Cyhoeddwyd: (2004)

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy
gan: Guiraud, S, et al.
Cyhoeddwyd: (2019)

Up-regulation of utrophin alleviates the dystrophic phenotype in the mdx mouse heart
gan: Sang, E, et al.
Cyhoeddwyd: (2000)

Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy
gan: Ruo Wu, et al.
Cyhoeddwyd: (2022-11-01)

Confirmation by immunogold labeling that utrophin is localised to the normal position of dystrophin in dystrophin-negative transgenic mouse muscle
gan: Cullen, M, et al.
Cyhoeddwyd: (2001)

A- and B-utrophin have different expression patterns and are differentially up-regulated in mdx muscle.
gan: Weir, A, et al.
Cyhoeddwyd: (2002)

Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin-/- Mice.
gan: Bruce E Markham, et al.
Cyhoeddwyd: (2015-01-01)

Generation of clusters of dystrophin revertant fibers requires muscle regeneration and tests the function of dystrophin/utrophin transgenes
gan: Yokota, T, et al.
Cyhoeddwyd: (2004)

Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis
gan: Hung-Chih Chen, et al.
Cyhoeddwyd: (2017-08-01)

A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.
gan: Cole, M, et al.
Cyhoeddwyd: (2002)

Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping
gan: Goyenvalle, A, et al.
Cyhoeddwyd: (2012)

Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.
gan: Goyenvalle, A, et al.
Cyhoeddwyd: (2012)

Micro-utrophin improves cardiac and skeletal muscle function of severely affected D2/mdx mice
gan: Kennedy, T, et al.
Cyhoeddwyd: (2018)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
Cyhoeddwyd: (2010-01-01)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
Cyhoeddwyd: (2010-01-01)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
Cyhoeddwyd: (2010-01-01)