Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
Recurrent reciprocal chromosomal translocations are present in more than 50% of leukemias. A deeper understanding of how they affect cancer initiation is essential for evaluating the origins of cancer and the potential for therapy based on the translocation products. Mouse models of chromosomal tran...
المؤلفون الرئيسيون: | Lobato, M, Metzler, M, Drynan, L, Forster, A, Pannell, R, Rabbitts, T |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2008
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مواد مشابهة
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Chromosomal translocation engineering to recapitulate primary events of human cancer.
حسب: Forster, A, وآخرون
منشور في: (2005) -
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.
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منشور في: (2003) -
The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
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Mouse models of human chromosomal translocations and approaches to cancer therapy.
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منشور في: (2001) -
The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells
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