Tetrahydrobiopterin-dependent eNOS coupling mediates endothelial regeneration and attenuates vein graft atherosclerosis in ApoE-KO mice

Tetrahydrobiopterin-dependent eNOS coupling mediates endothelial regeneration and attenuates vein graft atherosclerosis in ApoE-KO mice

Podrobná bibliografie
Hlavní autoři:	Ali, Z, Alp, N, Hu, Y, Xiao, Q, Akthar, A, Douglas, G, Tatham, A, deBono, J, Greaves, D, Xu, Q, Channon, K
Médium:	Conference item
Vydáno:	2007

Podobné jednotky

Increased eNOS coupling protects against vein graft accelerated atherosclerosis in ApoE-KO mice
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Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
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Tetrahydrobiopterin-dependent eNOS coupling determines vascular remodeling through accelerated endothelial regeneration
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Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
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Regulation of eNOS function by tetrahydrobiopterin in vascular disease
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Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
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Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
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Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
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Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
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Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
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Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
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Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
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CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
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Single dose oral tetrahydrobiopterin (BH4) leads to a prolonged increase in aortic BH4 levels in ApoE-KO mice
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5-methyl-tetrahydrofolate increases eNOS activity by preventing peroxynitrite-induced oxidation of tetrahydrobiopterin in human vessels
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Tetrahydrobiopterin- and glutathionylation-dependent regulation of eNOS coupling: Relationships revealed by eNOS glutathionylation mutants in cells with tet-regulated GTP cyclohydrolase I expression
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Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
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Mononuclear cell therapy attenuates atherosclerosis in apoE KO mice
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Broad spectrum adenoviral CC-chemokine blockade attenuates long term vein graft accelerated atherosclerosis in ApoE-knockout mice
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A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
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Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
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RAPID, DIRECT EFFECTS OF STATIN TREATMENT ON ARTERIAL REDOX STATE AND NITRIC OXIDE BIOAVAILABILITY IN HUMAN ATHEROSCLEROSIS VIA TETRAHYDROBIOPTERIN-MEDIATED ENOS COUPLING
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Intravenous infusion of 5-methyl-tetrahydrofolate rapidly improves eNOS Coupling. In human vessels by increasing tetrahydrobiopterin bioavailability
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Endothelial cell tetrahydrobiopterin: going with the flow.
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In-stent restenosis and atherosclerosis in a human saphenous vein graft.
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In-stent restenosis and atherosclerosis in a human saphenous vein graft.
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Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ
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Long-term oral tetrahydrobiopterin supplementation reduces atherosclerosis in apolipoprotein e knockout mice
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Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
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A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.
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eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice.
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Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
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Gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice.
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Tetrahydrobiopterin Slows the Progression of Atherosclerosis
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