Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium.
BACKGROUND/OBJECTIVES: Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires, which can over-report fruit and vegetable intake, the main source of vitamin C. This is the first stu...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797098569133457408 |
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| author | Hutchinson, J Lentjes, M Greenwood, D Burley, V Cade, J Cleghorn, C Threapleton, D Key, T Cairns, B Keogh, R Dahm, C Brunner, E Shipley, M Kuh, D Mishra, G Stephen, A Bhaniani, A Borgulya, G Khaw, K |
| author_facet | Hutchinson, J Lentjes, M Greenwood, D Burley, V Cade, J Cleghorn, C Threapleton, D Key, T Cairns, B Keogh, R Dahm, C Brunner, E Shipley, M Kuh, D Mishra, G Stephen, A Bhaniani, A Borgulya, G Khaw, K |
| author_sort | Hutchinson, J |
| collection | OXFORD |
| description | BACKGROUND/OBJECTIVES: Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires, which can over-report fruit and vegetable intake, the main source of vitamin C. This is the first study to investigate associations between vitamin C intake and breast cancer risk using food diaries. SUBJECTS/METHODS: Estimated dietary vitamin C intake was derived from 4-7 day food diaries pooled from five prospective studies in the UK Dietary Cohort Consortium. This nested case-control study of 707 incident breast cancer cases and 2144 matched controls examined breast cancer risk in relation to dietary vitamin C intake using conditional logistic regression adjusting for relevant covariates. Additionally, total vitamin C intake from supplements and diet was analysed in three cohorts. RESULTS: No evidence of associations was observed between breast cancer risk and vitamin C intake analysed for dietary vitamin C intake (odds ratios (OR)=0.98 per 60 mg/day, 95% confidence interval (CI): 0.88-1.09, P (trend)=0.7), dietary vitamin C density (OR=0.97 per 60 mg/day, 95% CI: 0.87-1.07, P (trend)=0.5 ) or total vitamin C intake (OR=1.01 per 60 mg/day, 95% CI: 0.99-1.03, P (trend)=0.3). Additionally, there was no significant association for post-menopausal women (OR=1.02 per 60 mg/day, 95% CI: 0.99-1.05, P (trend)=0.3). CONCLUSIONS: This pooled analysis of individual UK women found no evidence of significant associations between breast cancer incidence and dietary or total vitamin C intake derived uniquely from detailed diary recordings. |
| first_indexed | 2024-03-07T05:11:28Z |
| format | Journal article |
| id | oxford-uuid:dbb1c7b0-4f9b-4741-a5c5-b46bd03c97f8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:11:28Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:dbb1c7b0-4f9b-4741-a5c5-b46bd03c97f82022-03-27T09:12:28ZVitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dbb1c7b0-4f9b-4741-a5c5-b46bd03c97f8EnglishSymplectic Elements at Oxford2012Hutchinson, JLentjes, MGreenwood, DBurley, VCade, JCleghorn, CThreapleton, DKey, TCairns, BKeogh, RDahm, CBrunner, EShipley, MKuh, DMishra, GStephen, ABhaniani, ABorgulya, GKhaw, KBACKGROUND/OBJECTIVES: Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires, which can over-report fruit and vegetable intake, the main source of vitamin C. This is the first study to investigate associations between vitamin C intake and breast cancer risk using food diaries. SUBJECTS/METHODS: Estimated dietary vitamin C intake was derived from 4-7 day food diaries pooled from five prospective studies in the UK Dietary Cohort Consortium. This nested case-control study of 707 incident breast cancer cases and 2144 matched controls examined breast cancer risk in relation to dietary vitamin C intake using conditional logistic regression adjusting for relevant covariates. Additionally, total vitamin C intake from supplements and diet was analysed in three cohorts. RESULTS: No evidence of associations was observed between breast cancer risk and vitamin C intake analysed for dietary vitamin C intake (odds ratios (OR)=0.98 per 60 mg/day, 95% confidence interval (CI): 0.88-1.09, P (trend)=0.7), dietary vitamin C density (OR=0.97 per 60 mg/day, 95% CI: 0.87-1.07, P (trend)=0.5 ) or total vitamin C intake (OR=1.01 per 60 mg/day, 95% CI: 0.99-1.03, P (trend)=0.3). Additionally, there was no significant association for post-menopausal women (OR=1.02 per 60 mg/day, 95% CI: 0.99-1.05, P (trend)=0.3). CONCLUSIONS: This pooled analysis of individual UK women found no evidence of significant associations between breast cancer incidence and dietary or total vitamin C intake derived uniquely from detailed diary recordings. |
| spellingShingle | Hutchinson, J Lentjes, M Greenwood, D Burley, V Cade, J Cleghorn, C Threapleton, D Key, T Cairns, B Keogh, R Dahm, C Brunner, E Shipley, M Kuh, D Mishra, G Stephen, A Bhaniani, A Borgulya, G Khaw, K Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. |
| title | Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. |
| title_full | Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. |
| title_fullStr | Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. |
| title_full_unstemmed | Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. |
| title_short | Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. |
| title_sort | vitamin c intake from diary recordings and risk of breast cancer in the uk dietary cohort consortium |
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