Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.

Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.

Cotranscriptional cleavage mediated by a hammerhead ribozyme can affect alternative splicing if interposed between an exon and its intronic regulatory elements. This has been demonstrated using two different alternative splicing systems based on alpha-tropomyosin and fibronectin genes. We suggest th...

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Autors principals:	Gromak, N, Talotti, G, Proudfoot, N, Pagani, F
Format:	Journal article
Idioma:	English
Publicat:	2008

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