A novel image-based high throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease

A novel image-based high throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease

Glycogen storage disorders (GSDs) are caused by excessive accumulation of glycogen. Some GSDs (Adult Polyglucosan Body Disease (APBD), Tarui and Lafora diseases) are caused by intracellular accumulation of insoluble inclusions, called polyglucosan bodies (PB), which are chiefly composed of malconstr...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Solmesky, L, Khazanov, N, Senderowitz, H, Wang, P, Minassian, B, Ferreira, I, Yue, W, Lossos, A, Weil, M, Kakhlon, O
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Portland Press 2017

Antzeko izenburuak

Guaiacol as a drug candidate for treating adult polyglucosan body disease
nork: Kakhlon, O, et al.
Argitaratua: (2018)

Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism
nork: Or Kakhlon, et al.
Argitaratua: (2021-09-01)

Polyglucosan bodies in medullary catecholaminergic neurons in SUDEP
nork: Smriti Patodia, et al.
Argitaratua: (2021-01-01)

Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism
nork: Jun Wu, et al.
Argitaratua: (2024-04-01)

GYG1: A distal myopathy with polyglucosan bodies
nork: Stefan Nicolau, et al.
Argitaratua: (2020-09-01)

First Report on Fetal Cerebral Polyglucosan Bodies in Mucopolysaccharidosis Type VII
nork: Hazim Kadhim, et al.
Argitaratua: (2017-01-01)

Expanding the phenotype of RBCK1-associated polyglucosan body myopathy type 1
nork: Manuel Pühringer, et al.
Argitaratua: (2024-03-01)

Corrigendum to “Expanding the phenotype of RBCK1-associated polyglucosan body myopathy type 1”
nork: Manuel Pühringer, et al.
Argitaratua: (2024-03-01)

Proteomic investigations of adult polyglucosan body disease: insights into the pathobiology of a neurodegenerative disorder
nork: Joseph R. Abraham, et al.
Argitaratua: (2023-11-01)

P158: The diagnostic odyssey: A review of two patients with adult polyglucosan body disease
nork: Anusha Ebrahim, et al.
Argitaratua: (2023-01-01)

A case of polyglucosan body myopathy caused by an RBCK1 gene variant and literature review
nork: Qiqing Sun, et al.
Argitaratua: (2024-04-01)

Spastic ataxia with sensory neuropathy sans cerebral leukodystrophy in probable adult polyglucosan body disease
nork: Rohan Mahale, et al.
Argitaratua: (2023-01-01)

PAS GRANULES AND WASTEOSOMES: ASTROCYTIC POLYGLUCOSAN AGGREGATES IN THE AGING BRAIN
nork: Clara Romera, et al.
Argitaratua: (2023-10-01)

Clinical and genetic heterogeneity of adult polyglucosan body disease caused by GBE1 biallelic mutations in China
nork: Yikun Chen, et al.
Argitaratua: (2024-09-01)

Polyglucosan body myopathy 1 may cause cognitive impairment: a case report from China
nork: Lin Chen, et al.
Argitaratua: (2021-01-01)

Case report: Expanding the understanding of the adult polyglucosan body disease continuum: novel presentations, diagnostic pitfalls, and clinical pearls
nork: Matthew M. Gayed, et al.
Argitaratua: (2023-12-01)

Spectrophotometric Enzyme Assays for High-Throughput Screening
nork: Jean-Louis Reymond
Argitaratua: (2004-01-01)

Bioinformatics screening of colorectal-cancer causing molecular signatures through gene expression profiles to discover therapeutic targets and candidate agents
nork: Md Abu Horaira, et al.
Argitaratua: (2023-03-01)

A high-throughput screening approach to discovering good forms of inspired visual representation
nork: Pinto, Nicolas, et al.
Argitaratua: (2010)

A high-throughput drug screening identifies luteolin as a therapeutic candidate for pathological cardiac hypertrophy and heart failure
nork: Zhenya Wang, et al.
Argitaratua: (2023-03-01)

Enzyme assays : high-throughput screening, genetic selection and fingerprinting /
nork: Reymond, Jean-Louis
Argitaratua: (2006)

Apoptosis assessment in high-content and high-throughput screening assays
nork: Céline Rens, et al.
Argitaratua: (2021-06-01)

A High-Throughput Screening Approach to Discovering Good Forms of Biologically Inspired Visual Representation
nork: Cox, David D., et al.
Argitaratua: (2010)

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.
nork: Christelle Cabrol, et al.
Argitaratua: (2009-01-01)

A high-throughput screening approach to discovering good forms of biologically inspired visual representation.
nork: Nicolas Pinto, et al.
Argitaratua: (2009-11-01)

A medium-throughput protease assay for screening green plant material
nork: Christina Stonoha-Arther, et al.
Argitaratua: (2025-01-01)

Mining Chemical Activity Status from High-Throughput Screening Assays.
nork: Othman Soufan, et al.
Argitaratua: (2015-01-01)

A High-Throughput In Vitro Assay for Screening Rice Starch Digestibility
nork: Michelle R. Toutounji, et al.
Argitaratua: (2019-11-01)

An improved high-throughput screening assay for tunicamycin sensitivity in Arabidopsis seedlings
nork: Maggie E McCormack, et al.
Argitaratua: (2015-08-01)

Candidate ferroelectrics via ab initio high-throughput screening of polar materials
nork: Francesco Ricci, et al.
Argitaratua: (2024-01-01)

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds.
nork: Jair L Siqueira-Neto, et al.
Argitaratua: (2010-01-01)

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2
nork: Olujide O. Olubiyi, et al.
Argitaratua: (2020-07-01)

Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay.
nork: Helton J Wiggers, et al.
Argitaratua: (2013-01-01)

Discovering root causal genes with high-throughput perturbations
nork: Eric V Strobl, et al.
Argitaratua: (2025-03-01)

Development of a High-throughput Agar Colony Formation Assay to Identify Drug Candidates against Medulloblastoma
nork: Mohammed Sedeeq, et al.
Argitaratua: (2020-11-01)

A state-of-the-art methodology for high-throughput in silico vaccine discovery against protozoan parasites and exemplified with discovered candidates for Toxoplasma gondii
nork: Stephen J. Goodswen, et al.
Argitaratua: (2023-05-01)

Development of a cancer metastasis-on-chip assay for high throughput drug screening
nork: Lutfiye Yildiz Ozer, et al.
Argitaratua: (2024-01-01)

High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses
nork: Bara Cihlova, et al.
Argitaratua: (2021-06-01)

Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament
nork: Lorenzo Sborgi, et al.
Argitaratua: (2018-03-01)

Identification of new drug candidates against Trichomonas gallinae using high-throughput screening
nork: Shengfan Jing, et al.
Argitaratua: (2023-12-01)