A novel image-based high throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease

A novel image-based high throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease

Glycogen storage disorders (GSDs) are caused by excessive accumulation of glycogen. Some GSDs (Adult Polyglucosan Body Disease (APBD), Tarui and Lafora diseases) are caused by intracellular accumulation of insoluble inclusions, called polyglucosan bodies (PB), which are chiefly composed of malconstr...

Full description

Bibliographic Details
Main Authors:	Solmesky, L, Khazanov, N, Senderowitz, H, Wang, P, Minassian, B, Ferreira, I, Yue, W, Lossos, A, Weil, M, Kakhlon, O
Format:	Journal article
Language:	English
Published:	Portland Press 2017

Similar Items

Guaiacol as a drug candidate for treating adult polyglucosan body disease
by: Kakhlon, O, et al.
Published: (2018)

Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism
by: Or Kakhlon, et al.
Published: (2021-10-01)

Polyglucosan bodies in medullary catecholaminergic neurons in SUDEP
by: Smriti Patodia, et al.
Published: (2021-01-01)

GYG1: A distal myopathy with polyglucosan bodies
by: Stefan Nicolau, et al.
Published: (2020-09-01)

Expanding the phenotype of RBCK1-associated polyglucosan body myopathy type 1
by: Manuel Pühringer, et al.
Published: (2024-03-01)

Corrigendum to “Expanding the phenotype of RBCK1-associated polyglucosan body myopathy type 1”
by: Manuel Pühringer, et al.
Published: (2024-03-01)

Proteomic investigations of adult polyglucosan body disease: insights into the pathobiology of a neurodegenerative disorder
by: Joseph R. Abraham, et al.
Published: (2023-11-01)

Spastic ataxia with sensory neuropathy sans cerebral leukodystrophy in probable adult polyglucosan body disease
by: Rohan Mahale, et al.
Published: (2023-01-01)

P158: The diagnostic odyssey: A review of two patients with adult polyglucosan body disease
by: Anusha Ebrahim, et al.
Published: (2023-01-01)

Pathomorphogenesis of Glycogen-Ground Glass Hepatocytic Inclusions (Polyglucosan Bodies) in Children after Liver Transplantation
by: Francesco Callea, et al.
Published: (2022-09-01)

PAS GRANULES AND WASTEOSOMES: ASTROCYTIC POLYGLUCOSAN AGGREGATES IN THE AGING BRAIN
by: Clara Romera, et al.
Published: (2023-10-01)

Polyglucosan body myopathy 1 may cause cognitive impairment: a case report from China
by: Lin Chen, et al.
Published: (2021-01-01)

Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old
by: Nešić Slađan, et al.
Published: (2021-01-01)

Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases
by: Mitchell A. Sullivan, et al.
Published: (2019-04-01)

Proctalgia and constipation secondary to hypertrophic polyglucosan inclusion body myopathy of the internal anal sphincter: a case report
by: Ioanna G Panagiotopoulou, et al.
Published: (2018-10-01)

Case report: Expanding the understanding of the adult polyglucosan body disease continuum: novel presentations, diagnostic pitfalls, and clinical pearls
by: Matthew M. Gayed, et al.
Published: (2023-12-01)

Deciphering the Polyglucosan Accumulation Present in Lafora Disease Using an Astrocytic Cellular Model
by: Mireia Moreno-Estellés, et al.
Published: (2023-03-01)

Spectrophotometric Enzyme Assays for High-Throughput Screening
by: Jean-Louis Reymond
Published: (2004-01-01)

A high-throughput screening approach to discovering good forms of inspired visual representation
by: Pinto, Nicolas, et al.
Published: (2010)

Bioinformatics screening of colorectal-cancer causing molecular signatures through gene expression profiles to discover therapeutic targets and candidate agents
by: Md Abu Horaira, et al.
Published: (2023-03-01)

Enzyme assays : high-throughput screening, genetic selection and fingerprinting /
by: Reymond, Jean-Louis
Published: (2006)

An assay suitable for high throughput screening of anti-influenza drugs.
by: Lili Mao, et al.
Published: (2013-01-01)

A high-throughput drug screening identifies luteolin as a therapeutic candidate for pathological cardiac hypertrophy and heart failure
by: Zhenya Wang, et al.
Published: (2023-03-01)

Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics.
by: Richard L Cullum, et al.
Published: (2020-01-01)

A High-Throughput Screening Approach to Discovering Good Forms of Biologically Inspired Visual Representation
by: Cox, David D., et al.
Published: (2010)

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.
by: Christelle Cabrol, et al.
Published: (2009-01-01)

A high-throughput screening approach to discovering good forms of biologically inspired visual representation.
by: Nicolas Pinto, et al.
Published: (2009-11-01)

Ultrastrong nanocrystalline binary alloys discovered via high-throughput screening of the CoCr system
by: K. Wieczerzak, et al.
Published: (2021-07-01)

High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation
by: Yong Yu, et al.
Published: (2017-10-01)

Semi-Automated High-Throughput Substrate Screening Assay for Nucleoside Kinases
by: Katja F. Hellendahl, et al.
Published: (2021-10-01)

A High-Throughput In Vitro Assay for Screening Rice Starch Digestibility
by: Michelle R. Toutounji, et al.
Published: (2019-11-01)

An improved high-throughput screening assay for tunicamycin sensitivity in Arabidopsis seedlings
by: Maggie E McCormack, et al.
Published: (2015-08-01)

An enzymatic assay for high-throughput screening of cytidine-producing microbial strains.
by: Huina Dong, et al.
Published: (2015-01-01)

Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay.
by: Helton J Wiggers, et al.
Published: (2013-01-01)

Evaluation of QSAR Equations for Virtual Screening
by: Jacob Spiegel, et al.
Published: (2020-10-01)

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2
by: Olujide O. Olubiyi, et al.
Published: (2020-07-01)

Experimentally validated novel inhibitors of Helicobacter pylori phosphopantetheine adenylyltransferase discovered by virtual high-throughput screening.
by: Chao-Sheng Cheng, et al.
Published: (2013-01-01)

Candidate ferroelectrics via ab initio high-throughput screening of polar materials
by: Francesco Ricci, et al.
Published: (2024-01-01)

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds.
by: Jair L Siqueira-Neto, et al.
Published: (2010-01-01)

High-throughput screening identifies candidate drugs for the treatment of recurrent respiratory papillomatosis
by: Faris Alkhilaiwi, et al.
Published: (2019-12-01)