Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations

Charcot-Marie-Tooth disease type 2D (CMT2D) is a peripheral nerve disorder caused by dominant, toxic, gain-of-function mutations in the widely expressed, housekeeping gene, GARS The mechanisms underlying selective nerve pathology in CMT2D remain unresolved, as does the cause of the mild-to-moderate...

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書誌詳細
主要な著者: Sleigh, J, Dawes, J, West, S, Wei, N, Spaulding, E, Gómez-Martín, A, Zhang, Q, Burgess, R, Cader, M, Talbot, K, Yang, X, Bennett, D, Schiavo, G
フォーマット: Journal article
言語:English
出版事項: National Academy of Sciences 2017