Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury
<p>An important response of cartilage to injury is release of fibroblast growth factor 2 (FGF2) from the pericellular matrix. Deletion of FGF2 in mice, leads to worsening cartilage degradation both spontaneously and after surgical induction of osteoarthritis (OA); thereby indicating a chondrop...
| Main Authors: | , , , , |
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| 格式: | Conference item |
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Elsevier
2018
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| _version_ | 1826300096090734592 |
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| author | Khan, S Muhammad, H Scammahorn, J Dell'Accio, F Vincent, T |
| author_facet | Khan, S Muhammad, H Scammahorn, J Dell'Accio, F Vincent, T |
| author_sort | Khan, S |
| collection | OXFORD |
| description | <p>An important response of cartilage to injury is release of fibroblast growth factor 2 (FGF2) from the pericellular matrix. Deletion of FGF2 in mice, leads to worsening cartilage degradation both spontaneously and after surgical induction of osteoarthritis (OA); thereby indicating a chondroprotective role for FGF2. One mechanism by which FGF2 could protect the joint is by promoting intrinsic repair after injury.</p> <br/> <p>Healing of focal cartilage defects in mice has been shown to be dependent upon background strain and age, with young DBA1 mice having superior regenerative capacity. It is presumed that repair is dependent upon mesenchymal stem cell (MSC) migration to the injured site, followed by the process of chondrogenesis. Here we test whether FGF2 is involved in these processes.</p> |
| first_indexed | 2024-03-07T05:11:57Z |
| format | Conference item |
| id | oxford-uuid:dbdb76c5-6d92-4038-b35e-ab854b9fe7e7 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:11:57Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:dbdb76c5-6d92-4038-b35e-ab854b9fe7e72022-03-27T09:13:37ZFibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injuryConference itemhttp://purl.org/coar/resource_type/c_c94fuuid:dbdb76c5-6d92-4038-b35e-ab854b9fe7e7Symplectic Elements at OxfordElsevier2018Khan, SMuhammad, HScammahorn, JDell'Accio, FVincent, T<p>An important response of cartilage to injury is release of fibroblast growth factor 2 (FGF2) from the pericellular matrix. Deletion of FGF2 in mice, leads to worsening cartilage degradation both spontaneously and after surgical induction of osteoarthritis (OA); thereby indicating a chondroprotective role for FGF2. One mechanism by which FGF2 could protect the joint is by promoting intrinsic repair after injury.</p> <br/> <p>Healing of focal cartilage defects in mice has been shown to be dependent upon background strain and age, with young DBA1 mice having superior regenerative capacity. It is presumed that repair is dependent upon mesenchymal stem cell (MSC) migration to the injured site, followed by the process of chondrogenesis. Here we test whether FGF2 is involved in these processes.</p> |
| spellingShingle | Khan, S Muhammad, H Scammahorn, J Dell'Accio, F Vincent, T Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury |
| title | Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury |
| title_full | Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury |
| title_fullStr | Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury |
| title_full_unstemmed | Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury |
| title_short | Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury |
| title_sort | fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury |
| work_keys_str_mv | AT khans fibroblastgrowthfactor2promotesregenerationofcartilagebyattractingmesenchymalstemcellstothesiteofcartilageinjury AT muhammadh fibroblastgrowthfactor2promotesregenerationofcartilagebyattractingmesenchymalstemcellstothesiteofcartilageinjury AT scammahornj fibroblastgrowthfactor2promotesregenerationofcartilagebyattractingmesenchymalstemcellstothesiteofcartilageinjury AT dellacciof fibroblastgrowthfactor2promotesregenerationofcartilagebyattractingmesenchymalstemcellstothesiteofcartilageinjury AT vincentt fibroblastgrowthfactor2promotesregenerationofcartilagebyattractingmesenchymalstemcellstothesiteofcartilageinjury |