Low sensitivity of BinaxNOW RSV in infants
<p><strong>Background:</strong><br /> Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2020
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| _version_ | 1797098606852833280 |
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| author | Zuurbier, RP Bont, LJ Langedijk, AC Hamer, M Korsten, K Drysdale, SB Snape, MD Robinson, H Pollard, AJ Martinón-Torres, F Rodríguez-Tenreiro Sánchez, C Gómez-Carballa, A Dacosta-Urbieta, AI Heikkinen, T Cunningham, S van Houten, MA Wildenbeest, JG |
| author2 | RESCEU Investigators |
| author_facet | RESCEU Investigators Zuurbier, RP Bont, LJ Langedijk, AC Hamer, M Korsten, K Drysdale, SB Snape, MD Robinson, H Pollard, AJ Martinón-Torres, F Rodríguez-Tenreiro Sánchez, C Gómez-Carballa, A Dacosta-Urbieta, AI Heikkinen, T Cunningham, S van Houten, MA Wildenbeest, JG |
| author_sort | Zuurbier, RP |
| collection | OXFORD |
| description | <p><strong>Background:</strong><br />
Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized infants against the gold standard of molecular diagnosis.</p><br />
<p><strong>Methods:</strong><br />
We evaluated the performance of BN in infants with acute respiratory tract infections with different degrees of disease severity. Diagnostic accuracy of BN test results were compared with molecular diagnosis as reference standard.</p><br />
<p><strong>Results:</strong><br />
One hundred sixty-two respiratory samples from 148 children from October 2017 to February 2019 were studied. Sixty-six (40.7%) samples tested positive for RSV (30 hospitalizations, 31 medically attended episodes not requiring hospitalization, and 5 nonmedically attended episodes). Five of these samples tested positive with BN, leading to an overall sensitivity of BN of 7.6% (95% confidence interval [CI], 3.3%–16.5%) and a specificity of 100% (95% CI, 96.2%–100%). Sensitivity was low in all subgroups.</p><br />
<p><strong>Conclusions:</strong><br />
We found a low sensitivity of BN for point-of-care detection of RSV infection. BinaxNOW RSV should be used and interpreted with caution.</p> |
| first_indexed | 2024-03-07T05:12:01Z |
| format | Journal article |
| id | oxford-uuid:dbe28cbb-982a-4961-a37b-6d5c80750173 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:12:01Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:dbe28cbb-982a-4961-a37b-6d5c807501732022-03-27T09:13:53ZLow sensitivity of BinaxNOW RSV in infantsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dbe28cbb-982a-4961-a37b-6d5c80750173EnglishSymplectic ElementsOxford University Press2020Zuurbier, RPBont, LJLangedijk, ACHamer, MKorsten, KDrysdale, SBSnape, MDRobinson, HPollard, AJMartinón-Torres, FRodríguez-Tenreiro Sánchez, CGómez-Carballa, ADacosta-Urbieta, AIHeikkinen, TCunningham, Svan Houten, MAWildenbeest, JGRESCEU Investigators<p><strong>Background:</strong><br /> Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized infants against the gold standard of molecular diagnosis.</p><br /> <p><strong>Methods:</strong><br /> We evaluated the performance of BN in infants with acute respiratory tract infections with different degrees of disease severity. Diagnostic accuracy of BN test results were compared with molecular diagnosis as reference standard.</p><br /> <p><strong>Results:</strong><br /> One hundred sixty-two respiratory samples from 148 children from October 2017 to February 2019 were studied. Sixty-six (40.7%) samples tested positive for RSV (30 hospitalizations, 31 medically attended episodes not requiring hospitalization, and 5 nonmedically attended episodes). Five of these samples tested positive with BN, leading to an overall sensitivity of BN of 7.6% (95% confidence interval [CI], 3.3%–16.5%) and a specificity of 100% (95% CI, 96.2%–100%). Sensitivity was low in all subgroups.</p><br /> <p><strong>Conclusions:</strong><br /> We found a low sensitivity of BN for point-of-care detection of RSV infection. BinaxNOW RSV should be used and interpreted with caution.</p> |
| spellingShingle | Zuurbier, RP Bont, LJ Langedijk, AC Hamer, M Korsten, K Drysdale, SB Snape, MD Robinson, H Pollard, AJ Martinón-Torres, F Rodríguez-Tenreiro Sánchez, C Gómez-Carballa, A Dacosta-Urbieta, AI Heikkinen, T Cunningham, S van Houten, MA Wildenbeest, JG Low sensitivity of BinaxNOW RSV in infants |
| title | Low sensitivity of BinaxNOW RSV in infants |
| title_full | Low sensitivity of BinaxNOW RSV in infants |
| title_fullStr | Low sensitivity of BinaxNOW RSV in infants |
| title_full_unstemmed | Low sensitivity of BinaxNOW RSV in infants |
| title_short | Low sensitivity of BinaxNOW RSV in infants |
| title_sort | low sensitivity of binaxnow rsv in infants |
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