Post-traumatic OA (PTOA): what have we learned to advance osteoarthritis?
<p><strong>Purpose of review:</strong></p> <p>Current thinking in the study of post-traumatic osteoarthritis (PTOA) is overviewed: the osteoarthritis which follows acute joint injury. The review particularly highlights important publications in the last 18 months, also...
| Главный автор: | |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Wolters Kluwer
2020
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| _version_ | 1826300110524383232 |
|---|---|
| author | Watt, F |
| author_facet | Watt, F |
| author_sort | Watt, F |
| collection | OXFORD |
| description | <p><strong>Purpose of review:</strong></p>
<p>Current thinking in the study of post-traumatic osteoarthritis (PTOA) is
overviewed: the osteoarthritis which follows acute joint injury. The review particularly highlights important publications in the last 18 months, also reflecting on key older literature, in terms of what have we have we learned and have yet to learn from PTOA which can advance the OA field as a whole.</p>
<p><strong>Recent findings:</strong></p>
<p>PTOA is a mechanically-driven disease, giving insight into mechanical drivers for OA. A mechanosensitive molecular tissue injury response (which includes activation of pain, degradative and also repair pathways) is triggered by acute joint injury and seen in OA. Imaging features of PTOA
are highly similar to OA, arguing against it being a different phenotype. The inflammatory pathways activated by injury contribute to early joint symptoms. However later structural changes appear to be dissociated from traditional measures of synovial inflammation.</p>
<p><strong>Summary:</strong></p>
<p>PTOA remains an important niche in which to understand processes underlying OA and seek interventional targets. Whether PTOA has true molecular or clinical differences to OA as a whole remains to be understood. This knowledge is important for a field where animal modelling of the disease relies heavily on the link between injury and OA.</p> |
| first_indexed | 2024-03-07T05:12:10Z |
| format | Journal article |
| id | oxford-uuid:dbefbeec-40f7-4bd7-b97c-2dc6b9336568 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:12:10Z |
| publishDate | 2020 |
| publisher | Wolters Kluwer |
| record_format | dspace |
| spelling | oxford-uuid:dbefbeec-40f7-4bd7-b97c-2dc6b93365682022-03-27T09:14:11ZPost-traumatic OA (PTOA): what have we learned to advance osteoarthritis?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dbefbeec-40f7-4bd7-b97c-2dc6b9336568EnglishSymplectic ElementsWolters Kluwer2020Watt, F<p><strong>Purpose of review:</strong></p> <p>Current thinking in the study of post-traumatic osteoarthritis (PTOA) is overviewed: the osteoarthritis which follows acute joint injury. The review particularly highlights important publications in the last 18 months, also reflecting on key older literature, in terms of what have we have we learned and have yet to learn from PTOA which can advance the OA field as a whole.</p> <p><strong>Recent findings:</strong></p> <p>PTOA is a mechanically-driven disease, giving insight into mechanical drivers for OA. A mechanosensitive molecular tissue injury response (which includes activation of pain, degradative and also repair pathways) is triggered by acute joint injury and seen in OA. Imaging features of PTOA are highly similar to OA, arguing against it being a different phenotype. The inflammatory pathways activated by injury contribute to early joint symptoms. However later structural changes appear to be dissociated from traditional measures of synovial inflammation.</p> <p><strong>Summary:</strong></p> <p>PTOA remains an important niche in which to understand processes underlying OA and seek interventional targets. Whether PTOA has true molecular or clinical differences to OA as a whole remains to be understood. This knowledge is important for a field where animal modelling of the disease relies heavily on the link between injury and OA.</p> |
| spellingShingle | Watt, F Post-traumatic OA (PTOA): what have we learned to advance osteoarthritis? |
| title | Post-traumatic OA (PTOA): what have we learned to advance osteoarthritis? |
| title_full | Post-traumatic OA (PTOA): what have we learned to advance osteoarthritis? |
| title_fullStr | Post-traumatic OA (PTOA): what have we learned to advance osteoarthritis? |
| title_full_unstemmed | Post-traumatic OA (PTOA): what have we learned to advance osteoarthritis? |
| title_short | Post-traumatic OA (PTOA): what have we learned to advance osteoarthritis? |
| title_sort | post traumatic oa ptoa what have we learned to advance osteoarthritis |
| work_keys_str_mv | AT wattf posttraumaticoaptoawhathavewelearnedtoadvanceosteoarthritis |