Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

The HIV envelope has evolved a dense array of immunologically "self" carbohydrates that efficiently protect the virus from antibody recognition. Nonetheless, one broadly neutralising antibody, IgG1 2G12, has been shown to recognise a cluster of oligomannose glycans on the HIV-1 surface ant...

Full description

Bibliographic Details
Main Authors:	Scanlan, C, Ritchie, G, Baruah, K, Crispin, M, Harvey, D, Singer, B, Lucka, L, Wormald, M, Wentworth, P, Zitzmann, N, Rudd, P, Burton, D, Dwek, R
Format:	Journal article
Language:	English
Published:	Elsevier 2007

Similar Items

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.
by: Dunlop, D, et al.
Published: (2010)

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
by: Doores, K, et al.
Published: (2010)

Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis
by: Bowden, T, et al.
Published: (2012)

The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.
by: Bonomelli, C, et al.
Published: (2011)

Comparison of the N-linked glycans from soluble and GPI-anchored CD59 expressed in CHO cells.
by: Wheeler, S, et al.
Published: (2002)

An endoglycosidase with alternative glycan specificity allows broadened glycoprotein remodelling.
by: Goodfellow, J, et al.
Published: (2012)

Alpha-glucosidase inhibitors as potential broad based anti-viral agents
by: Mehta, A, et al.
Published: (1998)

Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells.
by: Rudd, P, et al.
Published: (2000)

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.
by: Pritchard, L, et al.
Published: (2015)

Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans
by: Rudd, P, et al.
Published: (1999)

Protocol for analyzing the biosynthesis and degradation of N-glycan precursors in mammalian cells
by: Yoichiro Harada, et al.
Published: (2021-03-01)

The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.
by: Camille Bonomelli, et al.
Published: (2011-01-01)

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
by: Pollock, S, et al.
Published: (2008)

N-linked glycan structures of the human Fcγ receptors produced in NS0 cells.
by: Cosgrave, E, et al.
Published: (2013)

O-glycan sialylation and the structure of the stalk-like region of the T cell co-receptor CD8.
by: Merry, A, et al.
Published: (2003)

Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems.
by: Royle, L, et al.
Published: (2003)

A novel form of carbohydrate recognition. The broadly neutralizing anti-HIV-1 antibody 2G12 recognizes a cluster of a1-2 mannose residues on the outer face of GP120
by: Rudd, P, et al.
Published: (2002)

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.
by: Scanlan, C, et al.
Published: (2002)

Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants
by: George W. Carnell, et al.
Published: (2023-02-01)

Sugar immunogens
by: Dwek, R, et al.
Published: (2009)

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
by: Pejchal, R, et al.
Published: (2011)

A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression.
by: Abd Hamid, U, et al.
Published: (2008)

HIV Co-Receptor Usage, Broadly Neutralising Antibodies, and Treatment
by: Nina Lin, et al.
Published: (2019-07-01)

O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.
by: Mattu, T, et al.
Published: (2000)

Restricted processing of glycans by endomannosidase in mammalian cells.
by: Kukushkin, N, et al.
Published: (2012)

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.
by: Astronomo, R, et al.
Published: (2008)

Emerging principles for the therapeutic exploitation of glycosylation.
by: Dalziel, M, et al.
Published: (2014)

Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns)
by: Branza-Nichita, N, et al.
Published: (2004)

Enhancing broadly neutralising antibody suppression of HIV by immune modulation and vaccination
by: Nel, C, et al.
Published: (2024)

Enhancing broadly neutralising antibody suppression of HIV by immune modulation and vaccination
by: Carla Nel, et al.
Published: (2024-11-01)

A family of novel, acidic N-glycans in Bowes melanoma tissue plasminogen activator have L2/HNK-1-bearing antennae, many with sulfation of the fucosylated chitobiose core.
by: Zamze, S, et al.
Published: (2001)

A potential survival strategy for human follicular lymphoma cells involving oligomannose glycans in the antigen-binding site
by: Radcliffe, C, et al.
Published: (2005)

Comprehensive N-glycan profiling of avian immunoglobulin Y
by: Gilgunn, S, et al.
Published: (2016)

HIV-1 diversity considerations for clinical studies of passively transferred broadly neutralising antibodies
by: K. Wagh, et al.
Published: (2019-12-01)

Towards the development of a broadly-neutralising vaccine against blood-stage Plasmodium falciparum
by: Douglas, A, et al.
Published: (2013)

Molecular mechanisms for enhancing the antigenicity of the carbohydrate epitope of the broadly neutralizing anti-HIV-1 antibody 2G12
by: Fulton, Z, et al.
Published: (2009)

Liposome treatment of viral infections
by: Dwek, R, et al.
Published: (2011)

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
by: Doores, K, et al.
Published: (2010)

Biosynthesis and Function of Extracellular Glycans in Cyanobacteria
by: Jan-Christoph Kehr, et al.
Published: (2015-01-01)

"Internal residue loss": rearrangements occurring during the fragmentation of carbohydrates derivatized at the reducing terminus.
by: Harvey, D, et al.
Published: (2002)