Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract
PURPOSE: APC*I1307K (c.3920T>A) is an inherited variant associated with colorectal tumour risk found almost exclusively in those of Ashkenazi Jewish ancestry. A single nucleotide substitution creates an oligo-adenine tract (A8) that appears to be inherently prone to further mis-pairing and sl...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Public Library of Science
2014
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