Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory study
<p><strong>Background:</strong> One in four individuals with cervicogenic headache (CeH) are unresponsive to therapy. Such therapy involves predominantly biomedical interventions targeting the upper-cervical spine. A recurring theme within musculoskeletal...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2023
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| _version_ | 1797111329890238464 |
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| author | Mingels, S Granitzer, M Schmid, AB Dankaerts, W |
| author_facet | Mingels, S Granitzer, M Schmid, AB Dankaerts, W |
| author_sort | Mingels, S |
| collection | OXFORD |
| description | <p><strong>Background:</strong> One in four individuals with cervicogenic headache (CeH) are unresponsive to therapy. Such therapy involves predominantly biomedical interventions targeting the upper-cervical spine. A recurring theme within musculoskeletal practice is the multidimensional nature and substantial heterogeneity of the condition. Such heterogeneity might be a reason for failure of a biomedical approach. Therefore, future studies investigating efficacy of managing CeH should ideally be based on identification, and better understanding of the heterogeneity of this population based on a comprehensive evaluation of clinically relevant contributing factors.</p>
<p><strong>Objectives:</strong> The objective was to map profiles of individuals with CeH based on pain modulation within a multidimensional context.</p>
<p><strong>Design:</strong> Pain Modulation Profiles (PMPs) of 18 adults (29–51 years) with CeH were mapped retrospectively.</p>
<p><strong>Method:</strong> The PMPs consisted of a Pain-Profile (bilateral suboccipital, erector spinae, anterior tibialis pressure pain thresholds), a Psycho-Social-Lifestyle-Profile (Depression, Anxiety, Stress Scale, Headache Impact test, Pittsburgh Sleep Quality Index), or a combination of both. Individual results were compared to normative data. Two Pain-Profiles were defined: normal or altered. Psycho-Social-Lifestyle-Profiles were categorized based on the number of altered psycho-social-lifestyle factors (range 0–5).</p>
<p><strong>Results:</strong> Mapping PMPs in individuals with CeH resulted in 50% presenting with a dominant altered Pain-Profile, 16.7% with a dominant altered Psycho-Social-Lifestyle-Profile, and 5.6% with dominant alterations in both Pain-Profile and Psycho-Social-Lifestyle-Profile.</p>
<p><strong>Conclusion:</strong> Our results indicate heterogeneity of PMPs within the CeH population. Replication of these results is needed through dynamic assessment of the Pain-Profile before evaluating if these profiles can help patient-stratification.</p> |
| first_indexed | 2024-03-07T08:07:15Z |
| format | Journal article |
| id | oxford-uuid:dc34f0e3-454c-43fe-b5aa-fd85103e6734 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:07:15Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:dc34f0e3-454c-43fe-b5aa-fd85103e67342023-11-07T06:39:44ZIndividual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dc34f0e3-454c-43fe-b5aa-fd85103e6734EnglishSymplectic ElementsElsevier2023Mingels, SGranitzer, MSchmid, ABDankaerts, W<p><strong>Background:</strong> One in four individuals with cervicogenic headache (CeH) are unresponsive to therapy. Such therapy involves predominantly biomedical interventions targeting the upper-cervical spine. A recurring theme within musculoskeletal practice is the multidimensional nature and substantial heterogeneity of the condition. Such heterogeneity might be a reason for failure of a biomedical approach. Therefore, future studies investigating efficacy of managing CeH should ideally be based on identification, and better understanding of the heterogeneity of this population based on a comprehensive evaluation of clinically relevant contributing factors.</p> <p><strong>Objectives:</strong> The objective was to map profiles of individuals with CeH based on pain modulation within a multidimensional context.</p> <p><strong>Design:</strong> Pain Modulation Profiles (PMPs) of 18 adults (29–51 years) with CeH were mapped retrospectively.</p> <p><strong>Method:</strong> The PMPs consisted of a Pain-Profile (bilateral suboccipital, erector spinae, anterior tibialis pressure pain thresholds), a Psycho-Social-Lifestyle-Profile (Depression, Anxiety, Stress Scale, Headache Impact test, Pittsburgh Sleep Quality Index), or a combination of both. Individual results were compared to normative data. Two Pain-Profiles were defined: normal or altered. Psycho-Social-Lifestyle-Profiles were categorized based on the number of altered psycho-social-lifestyle factors (range 0–5).</p> <p><strong>Results:</strong> Mapping PMPs in individuals with CeH resulted in 50% presenting with a dominant altered Pain-Profile, 16.7% with a dominant altered Psycho-Social-Lifestyle-Profile, and 5.6% with dominant alterations in both Pain-Profile and Psycho-Social-Lifestyle-Profile.</p> <p><strong>Conclusion:</strong> Our results indicate heterogeneity of PMPs within the CeH population. Replication of these results is needed through dynamic assessment of the Pain-Profile before evaluating if these profiles can help patient-stratification.</p> |
| spellingShingle | Mingels, S Granitzer, M Schmid, AB Dankaerts, W Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory study |
| title | Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory study |
| title_full | Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory study |
| title_fullStr | Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory study |
| title_full_unstemmed | Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory study |
| title_short | Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache – a retrospective exploratory study |
| title_sort | individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache a retrospective exploratory study |
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