Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis
We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1)...
| मुख्य लेखकों: | , , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Oxford University Press
2019
|
| _version_ | 1826311677929324544 |
|---|---|
| author | Li, YJ Wilkinson, KA Wilkinson, RJ Figaji, AA Rohlwink, UK |
| author_facet | Li, YJ Wilkinson, KA Wilkinson, RJ Figaji, AA Rohlwink, UK |
| author_sort | Li, YJ |
| collection | OXFORD |
| description | We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis. |
| first_indexed | 2024-03-07T08:13:15Z |
| format | Journal article |
| id | oxford-uuid:dc41b80d-f0ec-46d6-befb-178c1c02b1f5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:13:15Z |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:dc41b80d-f0ec-46d6-befb-178c1c02b1f52023-12-05T12:19:18ZElevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dc41b80d-f0ec-46d6-befb-178c1c02b1f5EnglishSymplectic ElementsOxford University Press2019Li, YJWilkinson, KAWilkinson, RJFigaji, AARohlwink, UKWe collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis. |
| spellingShingle | Li, YJ Wilkinson, KA Wilkinson, RJ Figaji, AA Rohlwink, UK Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis |
| title | Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis |
| title_full | Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis |
| title_fullStr | Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis |
| title_full_unstemmed | Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis |
| title_short | Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis |
| title_sort | elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis |
| work_keys_str_mv | AT liyj elevatedmatrixmetalloproteinaseconcentrationsoffernovelinsightintotheirroleinpediatrictuberculousmeningitis AT wilkinsonka elevatedmatrixmetalloproteinaseconcentrationsoffernovelinsightintotheirroleinpediatrictuberculousmeningitis AT wilkinsonrj elevatedmatrixmetalloproteinaseconcentrationsoffernovelinsightintotheirroleinpediatrictuberculousmeningitis AT figajiaa elevatedmatrixmetalloproteinaseconcentrationsoffernovelinsightintotheirroleinpediatrictuberculousmeningitis AT rohlwinkuk elevatedmatrixmetalloproteinaseconcentrationsoffernovelinsightintotheirroleinpediatrictuberculousmeningitis |