Penicillin binding protein substitutions co-occur with fluoroquinolone resistance in ‘epidemic’ lineages of multi drug-resistant Clostridioides difficile

Clostridioides difficile remains a key cause of healthcare-associated infection, with multidrug-resistant (MDR) lineages causing high-mortality (≥20%) outbreaks. Cephalosporin treatment is a long-established risk factor, and antimicrobial stewardship is a key control. A mechanism underlying raised c...

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Hlavní autoři: Dingle, K, Freeman, J, Didelot, X, Quan, TP, Eyre, DW, Swann, J, Spittal, WD, Clark, EV, Jolley, KA, Walker, AS, Wilcox, MH, Crook, DW
Médium: Journal article
Jazyk:English
Vydáno: American Society for Microbiology 2023