Resistance mechanisms to mTOR inhibition in renal cancer

Resistance mechanisms to mTOR inhibition in renal cancer

<p><b>Introduction</b>: Advanced clear cell renal cell cancer (CCRCC) is incurable, but molecularly targeted treatments have improved the prognosis. One such molecular target is the mammalian target of rapamycin (mTOR) and two rapalogues (everolimus and temsirolimus) have been lice...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолч:	Earwaker, P
Бусад зохиолчид:	Macaulay, V
Формат:	Дипломын ажил
Хэл сонгох:	English
Хэвлэсэн:	2015

Ижил төстэй зүйлс

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mTOR Signalling, Nutrients and Disease
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The mTOR pathway and integrating immune regulation.
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mTOR Signaling in Growth Control and Disease
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An emerging role of mTOR in lipid biosynthesis
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mTOR: dissecting regulation and mechanism of action to understand human disease.
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The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism
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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
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mTOR signalling and metabolic regulation of T cell differentiation.
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LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
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mTOR regulates memory CD8 T-cell differentiation.
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The identification of the mTOR-regulated phosphoproteome and a mediator of feedback inhibition to P13K-Akt
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Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells
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Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)
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mTOR-S6K1 pathway mediates cytoophidium assembly
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mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
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Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones.
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Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature.
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