Single-molecule DNA sensors and cages for transcription factors in vitro and in vivo

Single-molecule DNA sensors and cages for transcription factors in vitro and in vivo

<p>Gene regulation is vital to the success of all living organisms. Understanding this complex process is crucial to our knowledge of how cells function and how in some cases they can lead to debilitating or even fatal disease. In this thesis I focus on a set of DNA-binding proteins known as t...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Crawford, R
Awduron Eraill:	Kapanidis, A
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2011
Pynciau:	Physics Biophysics Biosensors Molecular biophysics (biochemistry) Nanostructures Nano-biotechnology

Eitemau Tebyg

DNA origami assembly
gan: Dunn, K, et al.
Cyhoeddwyd: (2014)

Probing GPCR-Gα interactions: a functional study by EM and SPR
gan: Adamson, RJ
Cyhoeddwyd: (2014)

Coarse-graining DNA for simulations of DNA nanotechnology.
gan: Doye, J, et al.
Cyhoeddwyd: (2013)

Single molecule studies of a voltage-gated potassium channel
gan: Angué, L
Cyhoeddwyd: (2013)

Single-molecule imaging of electroporated chemotaxis proteins in live bacteria
gan: Di Paolo, D
Cyhoeddwyd: (2015)

Fluorescence studies of influenza RNA and RNA polymerase
gan: Tomescu, A
Cyhoeddwyd: (2014)

Bioelectrochemistry by fluorescent cyclic voltammetry
gan: Mizzon, G
Cyhoeddwyd: (2012)

Structure-function studies of the bacterial dsDNA translocase FtsK
gan: Graham, JE
Cyhoeddwyd: (2010)

Pushing the boundaries: molecular dynamics simulations of complex biological membranes
gan: Parton, D
Cyhoeddwyd: (2011)

Preparing and sequencing ultra-long DNA molecules from single chromosomes
gan: Bauer, DLV
Cyhoeddwyd: (2013)

Studying protein-DNA interactions in vitro and in vivo using single-molecule photoswitching
gan: Uphoff, S
Cyhoeddwyd: (2013)

Investigating potential allostery in the transcription factor CREB
gan: Chung, NL
Cyhoeddwyd: (2020)

Studying marcomolecular transitions by NMR and computer simulations
gan: Stelzl, LS
Cyhoeddwyd: (2014)

Allosteric contributions of muscle nicotinic acetylcholine receptor residues in small-molecule interactions, disease and subunit assembly
gan: Epstein, M
Cyhoeddwyd: (2019)

Optimising protein synthesis in cell‐free systems, a review
gan: Angelo C. Batista, et al.
Cyhoeddwyd: (2021-03-01)

The regulation and inhibition of P-TEFb
gan: Hole, A
Cyhoeddwyd: (2011)

Biophysical and magnetic resonance studies of membrane proteins
gan: Orwick, M, et al.
Cyhoeddwyd: (2011)

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
gan: Smith, G, et al.
Cyhoeddwyd: (1997)

Structural studies of a membrane embedded chloride channel from E.Coli, a prokaryotic homologue of ClC channels
gan: Bowler, M, et al.
Cyhoeddwyd: (2001)

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
gan: Labro, A, et al.
Cyhoeddwyd: (2008)

Interactions of Neisseria meningitidis with the human immune system
gan: Harding, R
Cyhoeddwyd: (2015)

Biophysical studies of membrane protein structure and function
gan: Dijkman, P, et al.
Cyhoeddwyd: (2014)

Radiation damage in protein crystals examined under various conditions by different methods
gan: Garman, E, et al.
Cyhoeddwyd: (2009)

Determination of X-ray flux using silicon pin diodes
gan: Owen, R, et al.
Cyhoeddwyd: (2009)

The relationship between flagellar motor dynamics and the proton motive force
gan: Tipping, M, et al.
Cyhoeddwyd: (2011)

A biophysical study of the G protein coupled receptor neurotensin receptor 1
gan: Harding, PJ
Cyhoeddwyd: (2007)

Control of the unidirectional motor in Rhodobacter sphaeroides
gan: Brown, MT
Cyhoeddwyd: (2009)

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria
gan: Ng, HK
Cyhoeddwyd: (2012)

Structural, biochemical and computational studies of TRP channel transmembrane domain modularity
gan: Hanson, S
Cyhoeddwyd: (2014)

Molecular and structural characterisation of the human Fibrillin-1 N-C terminal interaction
gan: Yadin, D
Cyhoeddwyd: (2013)

Ion channels: structure of a molecular brake
gan: Sansom, M
Cyhoeddwyd: (1999)

The dielectric properties of water within model transbilayer pores
gan: Sansom, M, et al.
Cyhoeddwyd: (1997)

The molecular basis for ER tubule formation
gan: Brady, J
Cyhoeddwyd: (2015)

Substrate recognition by the proteasome
gan: Boehringer, J
Cyhoeddwyd: (2011)

Mechanisms of transcription regulation by full-length CREB
gan: Jeremie Gaudez
Cyhoeddwyd: (2023)

Structural studies of integrin activation
gan: Anthis, N, et al.
Cyhoeddwyd: (2009)

Single molecule fluorescence studies of viral transcription
gan: Periz Coloma, FJ
Cyhoeddwyd: (2014)

Fluorescence lifetime measurement with confocal endomicroscopy for direct analysis of tissue biochemistry in vivo
gan: Youngjae Won, et al.
Cyhoeddwyd: (2016-08-01)

Structural studies of cell surface signalling molecules for neuronal guidance and connectivity
gan: Mitakidis, N
Cyhoeddwyd: (2013)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
gan: Marles-Wright, J
Cyhoeddwyd: (2005)