Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.
Reperfusion of ischemic tissues elicits an acute inflammatory response involving serum complement, which is activated by circulating natural IgM specific to self-Ags exposed by ischemia. Recent reports demonstrating a role for the lectin pathway raise a question regarding the initial events in compl...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1826300224636715008 |
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| author | Zhang, M Takahashi, K Alicot, E Vorup-Jensen, T Kessler, B Thiel, S Jensenius, J Ezekowitz, R Moore, F Carroll, M |
| author_facet | Zhang, M Takahashi, K Alicot, E Vorup-Jensen, T Kessler, B Thiel, S Jensenius, J Ezekowitz, R Moore, F Carroll, M |
| author_sort | Zhang, M |
| collection | OXFORD |
| description | Reperfusion of ischemic tissues elicits an acute inflammatory response involving serum complement, which is activated by circulating natural IgM specific to self-Ags exposed by ischemia. Recent reports demonstrating a role for the lectin pathway raise a question regarding the initial events in complement activation. To dissect the individual roles of natural IgM and lectin in activation of complement, mice bearing genetic deficiency in early complement, IgM, or mannan-binding lectin were characterized in a mesenteric model of ischemia reperfusion injury. The results reveal that IgM binds initially to ischemic Ag providing a binding site for mannan-binding lectin which subsequently leads to activation of complement and injury. |
| first_indexed | 2024-03-07T05:13:55Z |
| format | Journal article |
| id | oxford-uuid:dc7f24e5-860d-4259-b3d9-65c751b14152 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:13:55Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:dc7f24e5-860d-4259-b3d9-65c751b141522022-03-27T09:18:11ZActivation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dc7f24e5-860d-4259-b3d9-65c751b14152EnglishSymplectic Elements at Oxford2006Zhang, MTakahashi, KAlicot, EVorup-Jensen, TKessler, BThiel, SJensenius, JEzekowitz, RMoore, FCarroll, MReperfusion of ischemic tissues elicits an acute inflammatory response involving serum complement, which is activated by circulating natural IgM specific to self-Ags exposed by ischemia. Recent reports demonstrating a role for the lectin pathway raise a question regarding the initial events in complement activation. To dissect the individual roles of natural IgM and lectin in activation of complement, mice bearing genetic deficiency in early complement, IgM, or mannan-binding lectin were characterized in a mesenteric model of ischemia reperfusion injury. The results reveal that IgM binds initially to ischemic Ag providing a binding site for mannan-binding lectin which subsequently leads to activation of complement and injury. |
| spellingShingle | Zhang, M Takahashi, K Alicot, E Vorup-Jensen, T Kessler, B Thiel, S Jensenius, J Ezekowitz, R Moore, F Carroll, M Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. |
| title | Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. |
| title_full | Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. |
| title_fullStr | Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. |
| title_full_unstemmed | Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. |
| title_short | Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. |
| title_sort | activation of the lectin pathway by natural igm in a model of ischemia reperfusion injury |
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