MLL associates specifically with a subset of transcriptionally active target genes.

MLL associates specifically with a subset of transcriptionally active target genes.

MLL (mixed-lineage leukemia) is a histone H3 Lys-4 specific methyltransferase that is a positive regulator of Hox expression. MLL rearrangements and amplification are common in acute lymphoid and myeloid leukemias and myelodysplastic disorders and are associated with abnormal up-regulation of Hox ge...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Milne, T, Dou, Y, Martin, M, Brock, H, Roeder, R, Hess, J
פורמט:	Journal article
שפה:	English
יצא לאור:	2005

פריטים דומים

MLL targets SET domain methyltransferase activity to Hox gene promoters.
מאת: Milne, T, et al.
יצא לאור: (2002)

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications.
מאת: Milne, T, et al.
יצא לאור: (2005)

Regulation of MLL1 H3K4 methyltransferase activity by its core components.
מאת: Dou, Y, et al.
יצא לאור: (2006)

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.
מאת: Martin, M, et al.
יצא לאור: (2003)

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
מאת: Dou, Y, et al.
יצא לאור: (2005)

Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia.
מאת: Marieke H van der Linden, et al.
יצא לאור: (2015-01-01)

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.
מאת: Milne, T, et al.
יצא לאור: (2005)

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.
מאת: Wilkinson, A, et al.
יצא לאור: (2013)

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
מאת: Milne, T, et al.
יצא לאור: (2010)

Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis
מאת: Milne, T, et al.
יצא לאור: (2010)

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction
מאת: Wilkinson, A, et al.
יצא לאור: (2013)

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction
מאת: Adam C. Wilkinson, et al.
יצא לאור: (2013-01-01)

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
מאת: Zeisig, B, et al.
יצא לאור: (2004)

The MLL family of proteins in normal development and disease
מאת: Milne, TA
יצא לאור: (2020)

Interaction of MLL amino terminal sequences with menin is required for transformation.
מאת: Caslini, C, et al.
יצא לאור: (2007)

MLL rearrangements in pediatric acute lymphoblastic and myeloblastic leukemias: MLL specific and lineage specific signatures
מאת: te Kronnie Geertruy, et al.
יצא לאור: (2009-06-01)

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.
מאת: Ballabio, E, et al.
יצא לאור: (2012)

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia
מאת: Milne, T, et al.
יצא לאור: (2022)

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
מאת: Biswas, D, et al.
יצא לאור: (2011)

FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
מאת: Allison V. Mitchell, et al.
יצא לאור: (2022-11-01)

MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy.
מאת: Milne, T
יצא לאור: (2014)

Isl1 promotes gene transcription through physical interaction with Set1/Mll complexes
מאת: Zhe Liu, et al.
יצא לאור: (2023-06-01)

Why are so many MLL lysine methyltransferases required for normal mammalian development?
מאת: Crump, N, et al.
יצא לאור: (2019)

MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy
מאת: Thomas A. Milne
יצא לאור: (2014-09-01)

Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).
מאת: Stefan Nagel, et al.
יצא לאור: (2012-01-01)

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
מאת: Young-Kwon Park, et al.
יצא לאור: (2021-03-01)

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
מאת: Yi Zhang, et al.
יצא לאור: (2019-05-01)

Leukaemia lineage specification caused by cell-specific Mll-Enl translocations.
מאת: Cano, F, et al.
יצא לאור: (2008)

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes
מאת: Shawn McClelland, et al.
יצא לאור: (2014-08-01)

Drug Repurposing for Targeting Acute Leukemia With KMT2A (MLL)—Gene Rearrangements
מאת: Alexia Tsakaneli, et al.
יצא לאור: (2021-09-01)

Transcription linked to recombination: a gene-internal promoter coincides with the recombination hot spot II of the human MLL gene.
מאת: Scharf, S, et al.
יצא לאור: (2007)

An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
מאת: Fang Cao, et al.
יצא לאור: (2010-11-01)

Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited
מאת: Sun Jian-Sheng, et al.
יצא לאור: (2006-01-01)

The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis.
מאת: Daser, A, et al.
יצא לאור: (2005)

Mutation of cancer driver MLL2 results in transcription stress and genome instability
מאת: Kantidakis, Theodoros, et al.
יצא לאור: (2016)

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.
מאת: Milne, T, et al.
יצא לאור: (1999)

Research progress in Menin-MLL interaction and its inhibitors in MLL-rearranged leukemia
מאת: FANG Xinyue, et al.
יצא לאור: (2024-10-01)

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.
מאת: Claudia V Andreu-Vieyra, et al.
יצא לאור: (2010-08-01)

Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo.
מאת: Fisher, F, et al.
יצא לאור: (1993)

Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes.
מאת: Michael Springer, et al.
יצא לאור: (2003-11-01)