MLL associates specifically with a subset of transcriptionally active target genes.

MLL associates specifically with a subset of transcriptionally active target genes.

MLL (mixed-lineage leukemia) is a histone H3 Lys-4 specific methyltransferase that is a positive regulator of Hox expression. MLL rearrangements and amplification are common in acute lymphoid and myeloid leukemias and myelodysplastic disorders and are associated with abnormal up-regulation of Hox ge...

Podrobná bibliografie
Hlavní autoři:	Milne, T, Dou, Y, Martin, M, Brock, H, Roeder, R, Hess, J
Médium:	Journal article
Jazyk:	English
Vydáno:	2005

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