Multistate redox-switchable ion transport using chalcogen-bonding anionophores
Synthetic supramolecular transmembrane anionophores have emerged as promising anticancer chemotherapeutics. However, key to their targeted application is achieving spatiotemporally controlled activity. Herein, we report a series of chalcogen-bonding diaryl tellurium-based transporters in which their...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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American Chemical Society
2023
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| _version_ | 1797108981763670016 |
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| author | Docker, A Johnson, TG Kuhn, H Zhang, Z Langton, MJ |
| author_facet | Docker, A Johnson, TG Kuhn, H Zhang, Z Langton, MJ |
| author_sort | Docker, A |
| collection | OXFORD |
| description | Synthetic supramolecular transmembrane anionophores have emerged as promising anticancer chemotherapeutics. However, key to their targeted application is achieving spatiotemporally controlled activity. Herein, we report a series of chalcogen-bonding diaryl tellurium-based transporters in which their anion binding potency and anionophoric activity are controlled through reversible redox cycling between Te oxidation states. This unprecedented in situ reversible multistate switching allows for switching between ON and OFF anion transport and is crucially achieved with biomimetic chemical redox couples. |
| first_indexed | 2024-03-07T07:34:05Z |
| format | Journal article |
| id | oxford-uuid:dca2c96a-bd94-496e-8eee-457728dd191f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:34:05Z |
| publishDate | 2023 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:dca2c96a-bd94-496e-8eee-457728dd191f2023-02-20T09:30:18ZMultistate redox-switchable ion transport using chalcogen-bonding anionophoresJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dca2c96a-bd94-496e-8eee-457728dd191fEnglishSymplectic ElementsAmerican Chemical Society2023Docker, AJohnson, TGKuhn, HZhang, ZLangton, MJSynthetic supramolecular transmembrane anionophores have emerged as promising anticancer chemotherapeutics. However, key to their targeted application is achieving spatiotemporally controlled activity. Herein, we report a series of chalcogen-bonding diaryl tellurium-based transporters in which their anion binding potency and anionophoric activity are controlled through reversible redox cycling between Te oxidation states. This unprecedented in situ reversible multistate switching allows for switching between ON and OFF anion transport and is crucially achieved with biomimetic chemical redox couples. |
| spellingShingle | Docker, A Johnson, TG Kuhn, H Zhang, Z Langton, MJ Multistate redox-switchable ion transport using chalcogen-bonding anionophores |
| title | Multistate redox-switchable ion transport using chalcogen-bonding anionophores |
| title_full | Multistate redox-switchable ion transport using chalcogen-bonding anionophores |
| title_fullStr | Multistate redox-switchable ion transport using chalcogen-bonding anionophores |
| title_full_unstemmed | Multistate redox-switchable ion transport using chalcogen-bonding anionophores |
| title_short | Multistate redox-switchable ion transport using chalcogen-bonding anionophores |
| title_sort | multistate redox switchable ion transport using chalcogen bonding anionophores |
| work_keys_str_mv | AT dockera multistateredoxswitchableiontransportusingchalcogenbondinganionophores AT johnsontg multistateredoxswitchableiontransportusingchalcogenbondinganionophores AT kuhnh multistateredoxswitchableiontransportusingchalcogenbondinganionophores AT zhangz multistateredoxswitchableiontransportusingchalcogenbondinganionophores AT langtonmj multistateredoxswitchableiontransportusingchalcogenbondinganionophores |