The role of topology and mechanics in uniaxially growing cell networks
In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this local heterogeneity, at the tissue level, the cell network i...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Royal Society
2020
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| _version_ | 1826300292080074752 |
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| author | Goriely, A Erlich, A Jones, G Tisseur, F Moulton, D |
| author_facet | Goriely, A Erlich, A Jones, G Tisseur, F Moulton, D |
| author_sort | Goriely, A |
| collection | OXFORD |
| description | In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this local heterogeneity, at the tissue level, the cell network is remarkably robust, as it is not easily perturbed by changes in the mechanical environment or the network connectivity. Through a network model, we relate global tissue structure (i.e. the cell network topology) and local growth mechanisms (growth laws) to the overall tissue response. Within this framework, we investigate the two main mechanical growth laws that have been proposed: stress-driven or straindriven growth. We show that in order to create a robust and stable tissue environment, networks with predominantly series connections are naturally driven by stress-driven growth, whereas networks with predominantly parallel connections are associated with strain-driven growth. |
| first_indexed | 2024-03-07T05:14:55Z |
| format | Journal article |
| id | oxford-uuid:dcd7977b-1dc5-494d-a71b-4d69e0ca2202 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:14:55Z |
| publishDate | 2020 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:dcd7977b-1dc5-494d-a71b-4d69e0ca22022022-03-27T09:20:38ZThe role of topology and mechanics in uniaxially growing cell networksJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dcd7977b-1dc5-494d-a71b-4d69e0ca2202EnglishSymplectic Elements at OxfordRoyal Society2020Goriely, AErlich, AJones, GTisseur, FMoulton, DIn biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this local heterogeneity, at the tissue level, the cell network is remarkably robust, as it is not easily perturbed by changes in the mechanical environment or the network connectivity. Through a network model, we relate global tissue structure (i.e. the cell network topology) and local growth mechanisms (growth laws) to the overall tissue response. Within this framework, we investigate the two main mechanical growth laws that have been proposed: stress-driven or straindriven growth. We show that in order to create a robust and stable tissue environment, networks with predominantly series connections are naturally driven by stress-driven growth, whereas networks with predominantly parallel connections are associated with strain-driven growth. |
| spellingShingle | Goriely, A Erlich, A Jones, G Tisseur, F Moulton, D The role of topology and mechanics in uniaxially growing cell networks |
| title | The role of topology and mechanics in uniaxially growing cell networks |
| title_full | The role of topology and mechanics in uniaxially growing cell networks |
| title_fullStr | The role of topology and mechanics in uniaxially growing cell networks |
| title_full_unstemmed | The role of topology and mechanics in uniaxially growing cell networks |
| title_short | The role of topology and mechanics in uniaxially growing cell networks |
| title_sort | role of topology and mechanics in uniaxially growing cell networks |
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