Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks
The idea of "date" and "party" hubs has been influential in the study of protein-protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date h...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Public Library of Science
2010
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| _version_ | 1797098826923769856 |
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| author | Agarwal, S Deane, C Porter, M Jones, N |
| author_facet | Agarwal, S Deane, C Porter, M Jones, N |
| author_sort | Agarwal, S |
| collection | OXFORD |
| description | The idea of "date" and "party" hubs has been influential in the study of protein-protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. Here, we show that the reported importance of date hubs to network connectivity can in fact be attributed to a tiny subset of them. Crucially, these few, extremely central, hubs do not display particularly low expression correlation, undermining the idea of a link between this quantity and hub function. The date/party distinction was originally motivated by an approximately bimodal distribution of hub co-expression; we show that this feature is not always robust to methodological changes. Additionally, topological properties of hubs do not in general correlate with co-expression. However, we find significant correlations between interaction centrality and the functional similarity of the interacting proteins. We suggest that thinking in terms of a date/party dichotomy for hubs in protein interaction networks is not meaningful, and it might be more useful to conceive of roles for protein-protein interactions rather than for individual proteins. |
| first_indexed | 2024-03-07T05:15:14Z |
| format | Journal article |
| id | oxford-uuid:dcef3269-e139-4b4b-a52c-b5676c8a83cd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:15:14Z |
| publishDate | 2010 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:dcef3269-e139-4b4b-a52c-b5676c8a83cd2022-03-27T09:21:22ZRevisiting date and party hubs: novel approaches to role assignment in protein interaction networksJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dcef3269-e139-4b4b-a52c-b5676c8a83cdEnglishSymplectic Elements at OxfordPublic Library of Science2010Agarwal, SDeane, CPorter, MJones, NThe idea of "date" and "party" hubs has been influential in the study of protein-protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. Here, we show that the reported importance of date hubs to network connectivity can in fact be attributed to a tiny subset of them. Crucially, these few, extremely central, hubs do not display particularly low expression correlation, undermining the idea of a link between this quantity and hub function. The date/party distinction was originally motivated by an approximately bimodal distribution of hub co-expression; we show that this feature is not always robust to methodological changes. Additionally, topological properties of hubs do not in general correlate with co-expression. However, we find significant correlations between interaction centrality and the functional similarity of the interacting proteins. We suggest that thinking in terms of a date/party dichotomy for hubs in protein interaction networks is not meaningful, and it might be more useful to conceive of roles for protein-protein interactions rather than for individual proteins. |
| spellingShingle | Agarwal, S Deane, C Porter, M Jones, N Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks |
| title | Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks |
| title_full | Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks |
| title_fullStr | Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks |
| title_full_unstemmed | Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks |
| title_short | Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks |
| title_sort | revisiting date and party hubs novel approaches to role assignment in protein interaction networks |
| work_keys_str_mv | AT agarwals revisitingdateandpartyhubsnovelapproachestoroleassignmentinproteininteractionnetworks AT deanec revisitingdateandpartyhubsnovelapproachestoroleassignmentinproteininteractionnetworks AT porterm revisitingdateandpartyhubsnovelapproachestoroleassignmentinproteininteractionnetworks AT jonesn revisitingdateandpartyhubsnovelapproachestoroleassignmentinproteininteractionnetworks |