Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons
Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite conside...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
eLife Sciences Publications
2016
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| _version_ | 1826300313263407104 |
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| author | Garas, F Shah, R Kormann, E Doig, N Vinchiati, F Nakamura, K Dorst, M Smith, Y Magill, P Sharott, A |
| author_facet | Garas, F Shah, R Kormann, E Doig, N Vinchiati, F Nakamura, K Dorst, M Smith, Y Magill, P Sharott, A |
| author_sort | Garas, F |
| collection | OXFORD |
| description | Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite considerable heterogeneity in both form and function. We demonstrate that the selective co-expression of another calcium-binding protein, secretagogin (Scgn), separates PV+ interneurons in rat and primate striatum into two topographically-, physiologically- and structurally-distinct cell populations. In rats, these two interneuron populations differed in their firing rates, patterns and relationships with cortical oscillations in vivo. Moreover, the axons of identified PV+/Scgn+ interneurons preferentially targeted the somata of SPNs of the so-called ‘direct pathway’, whereas PV+/Scgn- interneurons preferentially targeted ‘indirect pathway’ SPNs. These two populations of interneurons could therefore provide a substrate through which either of the striatal output pathways can be rapidly and selectively inhibited to subsequently mediate the expression of behavioral routines. |
| first_indexed | 2024-03-07T05:15:15Z |
| format | Journal article |
| id | oxford-uuid:dcef9f07-9f21-42e4-8500-afbf90b9cd9c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:15:15Z |
| publishDate | 2016 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:dcef9f07-9f21-42e4-8500-afbf90b9cd9c2022-03-27T09:21:25ZSecretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneuronsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dcef9f07-9f21-42e4-8500-afbf90b9cd9cEnglishSymplectic Elements at OxfordeLife Sciences Publications2016Garas, FShah, RKormann, EDoig, NVinchiati, FNakamura, KDorst, MSmith, YMagill, PSharott, ACorticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite considerable heterogeneity in both form and function. We demonstrate that the selective co-expression of another calcium-binding protein, secretagogin (Scgn), separates PV+ interneurons in rat and primate striatum into two topographically-, physiologically- and structurally-distinct cell populations. In rats, these two interneuron populations differed in their firing rates, patterns and relationships with cortical oscillations in vivo. Moreover, the axons of identified PV+/Scgn+ interneurons preferentially targeted the somata of SPNs of the so-called ‘direct pathway’, whereas PV+/Scgn- interneurons preferentially targeted ‘indirect pathway’ SPNs. These two populations of interneurons could therefore provide a substrate through which either of the striatal output pathways can be rapidly and selectively inhibited to subsequently mediate the expression of behavioral routines. |
| spellingShingle | Garas, F Shah, R Kormann, E Doig, N Vinchiati, F Nakamura, K Dorst, M Smith, Y Magill, P Sharott, A Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons |
| title | Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons |
| title_full | Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons |
| title_fullStr | Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons |
| title_full_unstemmed | Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons |
| title_short | Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons |
| title_sort | secretagogin expression delineates functionally specialized populations of striatal parvalbumin containing interneurons |
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