Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions.
Accumulating evidence has shown that a polymorphism in the promoter region of the serotonin-transporter (5-HTTLPR) modulates neural activation during the perceptual processing of emotional facial expressions. Furthermore, behavioral research has shown that attentional bias for negative information i...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797098836118732800 |
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| author | Antypa, N Cerit, H Kruijt, A Verhoeven, F Van der Does, A |
| author_facet | Antypa, N Cerit, H Kruijt, A Verhoeven, F Van der Does, A |
| author_sort | Antypa, N |
| collection | OXFORD |
| description | Accumulating evidence has shown that a polymorphism in the promoter region of the serotonin-transporter (5-HTTLPR) modulates neural activation during the perceptual processing of emotional facial expressions. Furthermore, behavioral research has shown that attentional bias for negative information is increased in s allele carriers. We examined the interactions among 5-HTTLPR (including SNP rs25531), life events and gender on the detection of facial emotions. We found a main effect of genotype, as well as moderating effects of childhood emotional abuse (CEA) and recent life events (RLE). S homozygous participants recognized negative facial expressions at a lower intensity than the other genotype groups. This effect was more evident in female participants and in participants who had experienced life events. The 5-HTTLPR genotype affects facial emotional perception, a process which is linked to a neurobiological response to threat and vulnerability to emotional disorders. |
| first_indexed | 2024-03-07T05:15:22Z |
| format | Journal article |
| id | oxford-uuid:dcfded24-1b0f-46f6-8126-8e6c3706b739 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:15:22Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:dcfded24-1b0f-46f6-8126-8e6c3706b7392022-03-27T09:21:46ZRelationships among 5-HTT genotype, life events and gender in the recognition of facial emotions.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dcfded24-1b0f-46f6-8126-8e6c3706b739EnglishSymplectic Elements at Oxford2011Antypa, NCerit, HKruijt, AVerhoeven, FVan der Does, AAccumulating evidence has shown that a polymorphism in the promoter region of the serotonin-transporter (5-HTTLPR) modulates neural activation during the perceptual processing of emotional facial expressions. Furthermore, behavioral research has shown that attentional bias for negative information is increased in s allele carriers. We examined the interactions among 5-HTTLPR (including SNP rs25531), life events and gender on the detection of facial emotions. We found a main effect of genotype, as well as moderating effects of childhood emotional abuse (CEA) and recent life events (RLE). S homozygous participants recognized negative facial expressions at a lower intensity than the other genotype groups. This effect was more evident in female participants and in participants who had experienced life events. The 5-HTTLPR genotype affects facial emotional perception, a process which is linked to a neurobiological response to threat and vulnerability to emotional disorders. |
| spellingShingle | Antypa, N Cerit, H Kruijt, A Verhoeven, F Van der Does, A Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. |
| title | Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. |
| title_full | Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. |
| title_fullStr | Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. |
| title_full_unstemmed | Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. |
| title_short | Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. |
| title_sort | relationships among 5 htt genotype life events and gender in the recognition of facial emotions |
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