Dual stressors of infection and warming can destabilize host microbiomes
Climate change is causing extreme heating events and intensifying infectious disease outbreaks. Animals harbour microbial communities, which are vital for their survival and fitness under stressful conditions. Understanding how microbiome structures change in response to infection and warming may be...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society
2024
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| _version_ | 1797113291633328128 |
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| author | Li, J Gao, YY Stevens, EJ King, K |
| author_facet | Li, J Gao, YY Stevens, EJ King, K |
| author_sort | Li, J |
| collection | OXFORD |
| description | Climate change is causing extreme heating events and intensifying infectious disease outbreaks.
Animals harbour microbial communities, which are vital for their survival and fitness under stressful
conditions. Understanding how microbiome structures change in response to infection and
warming may be important for forecasting host performance under global change. Here, we
evaluated alterations in the microbiomes of several wild Caenorhabditis elegans isolates spanning
a range of latitudes, upon warming temperatures and infection by the parasite Leucobacter
musarum. Using 16S rRNA sequencing, we found that microbiome diversity decreased, and
dispersion increased over time, with the former being more prominent in uninfected adults and the
latter aggravated by infection. Infection reduced dominance of specific microbial taxa, and
increased microbiome dispersion, indicating destabilizing effects on host microbial communities.
Exposing infected hosts to warming did not have an additive destabilizing effect on their
microbiomes. Moreover, warming during pre-adult development alleviated the destabilizing effects
of infection on host microbiomes. These results revealed an opposing interaction between biotic
and abiotic factors on microbiome structure. Lastly, we showed that increased microbiome
dispersion might be associated with decreased variability in microbial species interaction strength.
Overall, these findings improve our understanding of animal microbiome dynamics amidst climate
change and epidemics. |
| first_indexed | 2024-03-07T08:28:19Z |
| format | Journal article |
| id | oxford-uuid:dd090c9b-12fe-433b-a891-62cb15c87aee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-23T08:26:29Z |
| publishDate | 2024 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:dd090c9b-12fe-433b-a891-62cb15c87aee2024-04-12T09:19:22ZDual stressors of infection and warming can destabilize host microbiomesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dd090c9b-12fe-433b-a891-62cb15c87aeeEnglishSymplectic ElementsRoyal Society2024Li, JGao, YYStevens, EJKing, KClimate change is causing extreme heating events and intensifying infectious disease outbreaks. Animals harbour microbial communities, which are vital for their survival and fitness under stressful conditions. Understanding how microbiome structures change in response to infection and warming may be important for forecasting host performance under global change. Here, we evaluated alterations in the microbiomes of several wild Caenorhabditis elegans isolates spanning a range of latitudes, upon warming temperatures and infection by the parasite Leucobacter musarum. Using 16S rRNA sequencing, we found that microbiome diversity decreased, and dispersion increased over time, with the former being more prominent in uninfected adults and the latter aggravated by infection. Infection reduced dominance of specific microbial taxa, and increased microbiome dispersion, indicating destabilizing effects on host microbial communities. Exposing infected hosts to warming did not have an additive destabilizing effect on their microbiomes. Moreover, warming during pre-adult development alleviated the destabilizing effects of infection on host microbiomes. These results revealed an opposing interaction between biotic and abiotic factors on microbiome structure. Lastly, we showed that increased microbiome dispersion might be associated with decreased variability in microbial species interaction strength. Overall, these findings improve our understanding of animal microbiome dynamics amidst climate change and epidemics. |
| spellingShingle | Li, J Gao, YY Stevens, EJ King, K Dual stressors of infection and warming can destabilize host microbiomes |
| title | Dual stressors of infection and warming can destabilize host microbiomes |
| title_full | Dual stressors of infection and warming can destabilize host microbiomes |
| title_fullStr | Dual stressors of infection and warming can destabilize host microbiomes |
| title_full_unstemmed | Dual stressors of infection and warming can destabilize host microbiomes |
| title_short | Dual stressors of infection and warming can destabilize host microbiomes |
| title_sort | dual stressors of infection and warming can destabilize host microbiomes |
| work_keys_str_mv | AT lij dualstressorsofinfectionandwarmingcandestabilizehostmicrobiomes AT gaoyy dualstressorsofinfectionandwarmingcandestabilizehostmicrobiomes AT stevensej dualstressorsofinfectionandwarmingcandestabilizehostmicrobiomes AT kingk dualstressorsofinfectionandwarmingcandestabilizehostmicrobiomes |