Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages.
In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved in the genesis of new lymphatic vessels. Our results indicate that innate immune cells (CD11b+ macroph...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2005
|
| _version_ | 1797098859366711296 |
|---|---|
| author | Maruyama, K Ii, M Cursiefen, C Jackson, D Keino, H Tomita, M Van Rooijen, N Takenaka, H D'Amore, P Stein-Streilein, J Losordo, D Streilein, J |
| author_facet | Maruyama, K Ii, M Cursiefen, C Jackson, D Keino, H Tomita, M Van Rooijen, N Takenaka, H D'Amore, P Stein-Streilein, J Losordo, D Streilein, J |
| author_sort | Maruyama, K |
| collection | OXFORD |
| description | In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved in the genesis of new lymphatic vessels. Our results indicate that innate immune cells (CD11b+ macrophages, but not CD11c+ dendritic cells) physically contributed to lymphangiogenesis under pathological conditions and that bone marrow-derived CD11b+ macrophages expressed lymphatic endothelial markers such as LYVE-1 and Prox-1 under inflamed conditions in the corneal stromata of mice. Furthermore, blood vascular endothelial cells that expressed the Tie2 promoter did not contribute to newly formed lymphatic vessels under inflamed conditions. Our in vitro experiments demonstrated that CD11b+ macrophages alone were capable of forming tube-like structures that expressed markers of lymphatic endothelium such as LYVE-1 and podoplanin. The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis. |
| first_indexed | 2024-03-07T05:15:43Z |
| format | Journal article |
| id | oxford-uuid:dd1bc70a-2509-4f43-afd8-232a8a1569e9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:15:43Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:dd1bc70a-2509-4f43-afd8-232a8a1569e92022-03-27T09:22:41ZInflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dd1bc70a-2509-4f43-afd8-232a8a1569e9EnglishSymplectic Elements at Oxford2005Maruyama, KIi, MCursiefen, CJackson, DKeino, HTomita, MVan Rooijen, NTakenaka, HD'Amore, PStein-Streilein, JLosordo, DStreilein, JIn the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved in the genesis of new lymphatic vessels. Our results indicate that innate immune cells (CD11b+ macrophages, but not CD11c+ dendritic cells) physically contributed to lymphangiogenesis under pathological conditions and that bone marrow-derived CD11b+ macrophages expressed lymphatic endothelial markers such as LYVE-1 and Prox-1 under inflamed conditions in the corneal stromata of mice. Furthermore, blood vascular endothelial cells that expressed the Tie2 promoter did not contribute to newly formed lymphatic vessels under inflamed conditions. Our in vitro experiments demonstrated that CD11b+ macrophages alone were capable of forming tube-like structures that expressed markers of lymphatic endothelium such as LYVE-1 and podoplanin. The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis. |
| spellingShingle | Maruyama, K Ii, M Cursiefen, C Jackson, D Keino, H Tomita, M Van Rooijen, N Takenaka, H D'Amore, P Stein-Streilein, J Losordo, D Streilein, J Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. |
| title | Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. |
| title_full | Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. |
| title_fullStr | Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. |
| title_full_unstemmed | Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. |
| title_short | Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. |
| title_sort | inflammation induced lymphangiogenesis in the cornea arises from cd11b positive macrophages |
| work_keys_str_mv | AT maruyamak inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT iim inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT cursiefenc inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT jacksond inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT keinoh inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT tomitam inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT vanrooijenn inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT takenakah inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT damorep inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT steinstreileinj inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT losordod inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages AT streileinj inflammationinducedlymphangiogenesisinthecorneaarisesfromcd11bpositivemacrophages |