Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP.

Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP.

Tumor necrosis factor-alpha is released from cells by a proteolytic cleavage. Previous work suggested that a specific, non-matrix metalloproteinase carries out this cleavage, but matrix metalloproteinases have also been implicated. In this paper, we report that none of the matrix metalloproteinases...

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Detalhes bibliográficos
Main Authors: Black, R, Durie, F, Otten-Evans, C, Miller, R, Slack, J, Lynch, D, Castner, B, Mohler, K, Gerhart, M, Johnson, R, Itoh, Y, Okada, Y, Nagase, H
Formato: Journal article
Idioma:English
Publicado em: 1996

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