The role of antibody concentration and avidity in antiviral protection.
Neutralizing antibodies are necessary and sufficient for protection against infection with vesicular stomatitis virus (VSV). The in vitro neutralization capacities and in vivo protective capacities of a panel of immunoglobulin G monoclonal antibodies to the glycoprotein of VSV were evaluated. In vit...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1826300411198308352 |
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| author | Bachmann, M Kalinke, U Althage, A Freer, G Burkhart, C Roost, H Aguet, M Hengartner, H Zinkernagel, R |
| author_facet | Bachmann, M Kalinke, U Althage, A Freer, G Burkhart, C Roost, H Aguet, M Hengartner, H Zinkernagel, R |
| author_sort | Bachmann, M |
| collection | OXFORD |
| description | Neutralizing antibodies are necessary and sufficient for protection against infection with vesicular stomatitis virus (VSV). The in vitro neutralization capacities and in vivo protective capacities of a panel of immunoglobulin G monoclonal antibodies to the glycoprotein of VSV were evaluated. In vitro, neutralizing activity correlated with avidity and with neutralization rate constant, a measure of on-rate. However, in vivo, protection was independent of immunoglobulin subclass, avidity, neutralization rate constant, and in vitro neutralizing activity; above a minimal avidity threshold, protection depended simply on a minimum serum concentration. These two biologically defined thresholds of antibody specificity offer hope for the development of adoptive therapy with neutralizing antibodies. |
| first_indexed | 2024-03-07T05:16:46Z |
| format | Journal article |
| id | oxford-uuid:dd7a5bd3-1cbb-4871-9139-504a365805c4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:16:46Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:dd7a5bd3-1cbb-4871-9139-504a365805c42022-03-27T09:25:14ZThe role of antibody concentration and avidity in antiviral protection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dd7a5bd3-1cbb-4871-9139-504a365805c4EnglishSymplectic Elements at Oxford1997Bachmann, MKalinke, UAlthage, AFreer, GBurkhart, CRoost, HAguet, MHengartner, HZinkernagel, RNeutralizing antibodies are necessary and sufficient for protection against infection with vesicular stomatitis virus (VSV). The in vitro neutralization capacities and in vivo protective capacities of a panel of immunoglobulin G monoclonal antibodies to the glycoprotein of VSV were evaluated. In vitro, neutralizing activity correlated with avidity and with neutralization rate constant, a measure of on-rate. However, in vivo, protection was independent of immunoglobulin subclass, avidity, neutralization rate constant, and in vitro neutralizing activity; above a minimal avidity threshold, protection depended simply on a minimum serum concentration. These two biologically defined thresholds of antibody specificity offer hope for the development of adoptive therapy with neutralizing antibodies. |
| spellingShingle | Bachmann, M Kalinke, U Althage, A Freer, G Burkhart, C Roost, H Aguet, M Hengartner, H Zinkernagel, R The role of antibody concentration and avidity in antiviral protection. |
| title | The role of antibody concentration and avidity in antiviral protection. |
| title_full | The role of antibody concentration and avidity in antiviral protection. |
| title_fullStr | The role of antibody concentration and avidity in antiviral protection. |
| title_full_unstemmed | The role of antibody concentration and avidity in antiviral protection. |
| title_short | The role of antibody concentration and avidity in antiviral protection. |
| title_sort | role of antibody concentration and avidity in antiviral protection |
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