Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases

Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases

<p>The research described in this thesis concerns the development of novel small molecule inhibitors of biologically relevant nucleophilic hydrolases, i.e. β-lactamases, SARS-CoV-2 main protease (Mpro) and elastases, which are therapeutic targets for combatting public health threats associated...

書目詳細資料
主要作者:	Gayatri
其他作者:	Schofield, C
格式:	Thesis
語言:	English
出版:	2024
主題:	Protease inhibitors Drug interactions Enzyme inhibitors Organic compounds > Synthesis Chemistry, Organic Mechanism of action (Biochemistry) Binding sites (Biochemistry) Structure-activity relationships (Biochemistry) Dose-response relationship (Biochemistry) Pharmaceutical chemistry

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