Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases

Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases

<p>The research described in this thesis concerns the development of novel small molecule inhibitors of biologically relevant nucleophilic hydrolases, i.e. β-lactamases, SARS-CoV-2 main protease (Mpro) and elastases, which are therapeutic targets for combatting public health threats associated...

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Chi tiết về thư mục
Tác giả chính: Gayatri
Tác giả khác: Schofield, C
Định dạng: Luận văn
Ngôn ngữ:English
Được phát hành: 2024
Những chủ đề:
Protease inhibitors
Drug interactions
Enzyme inhibitors
Organic compounds > Synthesis
Chemistry, Organic
Mechanism of action (Biochemistry)
Binding sites (Biochemistry)
Structure-activity relationships (Biochemistry)
Dose-response relationship (Biochemistry)
Pharmaceutical chemistry

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