Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling

Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling

Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM) increase myofilament Ca2+ sensitivity. Mouse models exhibit increased Ca2+ buffering and arrhythmias, and we hypothesized that these changes are primary effects of the mutations (independent of compensatory c...

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Bibliographic Details
Main Authors:	Robinson, P, Liu, X, Sparrow, A, Patel, S, Zhang, Y, Casadei, B, Watkins, H, Redwood, C
Format:	Journal article
Language:	English
Published:	American Society for Biochemistry and Molecular Biology 2018

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