Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling

Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling

Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM) increase myofilament Ca2+ sensitivity. Mouse models exhibit increased Ca2+ buffering and arrhythmias, and we hypothesized that these changes are primary effects of the mutations (independent of compensatory c...

書誌詳細
主要な著者:	Robinson, P, Liu, X, Sparrow, A, Patel, S, Zhang, Y, Casadei, B, Watkins, H, Redwood, C
フォーマット:	Journal article
言語:	English
出版事項:	American Society for Biochemistry and Molecular Biology 2018

類似資料

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations
著者:: Sparrow, AJ, 等
出版事項: (2020)

Cardiomyopathy-Causing Mutations in Thin Filament Regulatory Proteins Acutely Affeect Ca2+-Buffering and Ca2+-Dependent Signalling In Situ
著者:: Robinson, P, 等
出版事項: (2013)

Cardiomyopathy-causing mutations in cardiac thin filament regulatory proteins acutely affect Ca2+ buffering and Ca2+ dependant signalling in situ
著者:: Robinson, P, 等
出版事項: (2012)

Measurement of myofilament-localised calcium dynamics in adult cardiomyocytes and the effect of hypertrophic cardiomyopathy mutations
著者:: Sparrow, A, 等
出版事項: (2019)

Ion Channel Impairment and Myofilament Ca<sup>2+</sup> Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy
著者:: Lorenzo Santini, 等
出版事項: (2021-10-01)

Altered contractile mechanics and Ca2+ handling contribute to cardiomyopathy pathogenesis
著者:: Turtle, C
出版事項: (2015)

Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart
著者:: Luigi Zechini, 等
出版事項: (2022-09-01)

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation
著者:: Messer, A, 等
出版事項: (2016)

A troponin I mutant known to cause hypertrophic cardiomyopathy shows reduced inhibition of Ca2+ independent tension
著者:: Burton, D, 等
出版事項: (2000)

Right‐ventricular dysfunction in HFpEF is linked to altered cardiomyocyte Ca2+ homeostasis and myofilament sensitivity
著者:: Niklas Hegemann, 等
出版事項: (2021-08-01)

Overexpression of SERCA2a alters endoplasmic reticulum Ca2+ handling in WKY but not SHR cardiac sympathetic neurons. A role for altered intracellular Ca2+ handling in hypertensive sympathoexcitation?
著者:: Shanks, J, 等
出版事項: (2017)

High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca2+ in obese rats
著者:: Matheus Corteletti dos Santos, 等
出版事項: (2024-10-01)

Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca²⁺, and activate NFAT and Akt signaling
著者:: Robinson, P, 等
出版事項: (2020)

Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament
著者:: Naoto Tadano, 等
出版事項: (2009-01-01)

INTRACELLULAR Ca2+ HOMEOSTASIS
著者:: Shahdevi Nandar Kurniawan
出版事項: (2015-01-01)

Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster.
著者:: Manuela Santalla, 等
出版事項: (2014-01-01)

The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament
著者:: Fergus M. Payne, 等
出版事項: (2024-03-01)

Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin
著者:: Alice Sheehan, 等
出版事項: (2018-03-01)

By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2+.
著者:: Lukas Jaroslaw Motloch, 等
出版事項: (2016-01-01)

Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells
著者:: Zhang, H, 等
出版事項: (2003)

The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy
著者:: Helena M. Viola, PhD, 等
出版事項: (2016-01-01)

Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model
著者:: Sabrina Stücker, 等
出版事項: (2017-08-01)

Using fluorescence emission spectroscopy to asses the Ca2+ affinity of reconstituted troponin and thin filaments containing cardiomyopathy causing mutations of troponin and alpha-tropomyosin
著者:: Robinson, P, 等
出版事項: (2007)

Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
著者:: Bayliss, C, 等
出版事項: (2013)

Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
著者:: Felipe Gonçalves dos Santos de Sá, 等
出版事項: (2015-01-01)

Energy imbalance alters Ca2+ handling and excitability of POMC neurons
著者:: Lars Paeger, 等
出版事項: (2017-08-01)

STIM2 regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes
著者:: Mi Ri Oh, 等
出版事項: (2017-12-01)

P387Knock-in mouse model of PRKAG2 cardiomyopathy (R299Q) exhibits altered Ca2+-dependent cardiac contractility and reduced protein kinase A activity.
著者:: Turtle, C, 等
出版事項: (2014)

Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.
著者:: Swietach, P, 等
出版事項: (2013)

Caldaret, an Intracellular Ca2+ Handling Modulator, Limits Infarct Size of Reperfused Canine Heart
著者:: Hisashi Kawasumi, 等
出版事項: (2007-01-01)

The Role of the Na+/Ca2+ Exchanger in Aberrant Intracellular Ca2+ in Cardiomyocytes of Chagas-Infected Rodents
著者:: Jose R. Lopez, 等
出版事項: (2022-07-01)

Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release
著者:: E.N. Chini
出版事項: (2002-05-01)

Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes
著者:: Robinson, P, 等
出版事項: (2023)

Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations.
著者:: Gerbino, A, 等
出版事項: (2005)

Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells.
著者:: Gall, D, 等
出版事項: (1999)

Caffeine modulates Ca2+ receptor activation in isolated rat osteoclasts and induces intracellular Ca2+ release.
著者:: Shankar, V, 等
出版事項: (1995)

Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.
著者:: Xiao-Chen Li, 等
出版事項: (2011-01-01)

Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs
著者:: Atsushi Sugiyama, 等
出版事項: (2019-03-01)

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein.
著者:: Redwood, C, 等
出版事項: (2000)

Intracellular Ca2 + Imbalance Critically Contributes to Paraptosis
著者:: Eunhee Kim, 等
出版事項: (2021-01-01)