Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling
Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM) increase myofilament Ca2+ sensitivity. Mouse models exhibit increased Ca2+ buffering and arrhythmias, and we hypothesized that these changes are primary effects of the mutations (independent of compensatory c...
Główni autorzy: | Robinson, P, Liu, X, Sparrow, A, Patel, S, Zhang, Y, Casadei, B, Watkins, H, Redwood, C |
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Format: | Journal article |
Język: | English |
Wydane: |
American Society for Biochemistry and Molecular Biology
2018
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